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A total of 114 subjects (41 depressed, 20 schizophrenic, 15 manic, and 38 normal controls) underwent lumbar puncture and their CSF was analyzed for levels of tyrosine, tryptophan, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol (MHPG), choline, gamma-aminobutyric acid (GABA), and calcium. Results showed that(More)
To assess the relationship between the DSM-III criteria for attention deficit disorder with hyperactivity (ADDH) and the DSM-III-R criteria for attention-deficit hyperactivity disorder (ADHD), children from an inner city parochial school were evaluated using a 30-item teacher questionnaire consisting of the DMS-III and DSM-III-R criteria for these(More)
Whole blood serotonin and tryptophan were measured in 87 normal subjects and in 40 autistic subjects. Whole blood serotonin concentrations (mean +/- SE) were significantly higher in drug-free (N = 21) autistics (205 +/- 16 ng/ml) than in normals (136 +/- 5.4 ng/ml). The Gaussian distribution of serotonin levels in the unmedicated autistic group suggests the(More)
Published reports of toxic hallucinosis during treatment with methylphenidate are rare. Two cases are described and it is suggested that methylphenidate-induced hallucinosis is more common than has been appreciated. Symptoms may be understood in terms of dose-related effects at pre- and postsynaptic receptors. Two other hypotheses that may clarify(More)
Advances in information concerning brain function in animals and advances in analytical neurochemical methods for determining extremely low levels of compounds in physiological fluids have opened great opportunities for clinical neurochemical studies of autism. Nevertheless, the behavioral deficits in autistic individuals are major obstacles to(More)
Maturation of monoamine neuronal systems was studied by measuring cerebrospinal fluid metabolites of dopamine (homovanillic acid) and serotonin (5-hydroxyindoleacetic acid) in 38 children with epilepsy and other neurological disorders, to whom probenecid had previously been administered. The turnover of brain dopamine decreased with age. This ontogenetic(More)