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BACKGROUND Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a(More)
BACKGROUND Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional(More)
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This paper proposes a new approach to sparse-signal detection called the horseshoe estimator. We show that the horseshoe is a close cousin of the lasso in that it arises from the same class of multivariate scale mixtures of normals, but that it is almost universally superior to the double-exponential prior at handling sparsity. A theoretical framework is(More)
We study the classic problem of choosing a prior distribution for a location parameter β = (β 1 ,. .. , βp) as p grows large. First, we study the standard " global-local shrinkage " approach, based on scale mixtures of normals. Two theorems are presented which characterize certain desirable properties of shrinkage priors for sparse problems. Next, we review(More)
This paper presents a general, fully Bayesian framework for sparse supervised-learning problems based on the horseshoe prior. The horseshoe prior is a member of the family of multivariate scale mixtures of normals, and is therefore closely related to widely used approaches for sparse Bayesian learning, including , among others, Laplacian priors (e.g. the(More)
OBJECTIVE Aggression is common in children and adolescents admitted to psychiatric inpatient units. Few interventions for reducing aggressive behaviors have been identified. This study aimed to evaluate the impact of a milieu-based behavioral management program on the frequency of aggressive behaviors in a child and adolescent mental health inpatient unit.(More)
BACKGROUND The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary(More)
OBJECTIVE The Global Burden of Disease Study 2010 (GBD 2010) is the first to include conduct disorder (CD) and attention-deficit/hyperactivity disorder (ADHD) for burden quantification. METHOD A previous systematic review pooled the available epidemiological data for CD and ADHD, and predicted prevalence by country, region, age and sex for each disorder.(More)
BACKGROUND The most recent Global Burden of Disease Study (GBD 2010) is the first to include attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) for burden quantification. We present the epidemiological profiles of ADHD and CD across three time periods for 21 world regions. METHODS A systematic review of global epidemiology was(More)