Structural analysis of a new variant hemoglobin revealed tryptic peptides with the amino acid composition of normal delta-globin, except for two internal peptides, which had the compositions of normal beta-globin. The most likely explanation for these findings is that a double, nonhomologous crossover between the delta-and beta-globin genes had occurred.
Baboons exposed to acute hemolytic stres increase their production of fetal hemoglobin (HbF). Although the maximal in vivo HbF levels attained in 5 treated animals varied from 6.4% to 34.8%, their cultured bone marrow erythroid cells reverted to the fetal pattern of hemoglobin synthesis. These data suggest that HbF synthesis is modulated by the interaction… (More)
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Our multidisciplinary team developed a new set of discharge instructions for five common emergency department diagnoses using recommended tools for creating literacy-appropriate and patient-centered education materials. We found that the recommended tools for document creation were essential in constructing the new instructions. However, while the tools… (More)
We read with interest the article by Linder, Schnipper, and Middleton comparing dictation , free-text typing, and structured data entry to quality outcomes. 1 The authors conclude that using dictation appeared to provide a lower quality of care, but that conclusion seems unsupported by the reported results. Most importantly, the authors themselves note that… (More)
The authors make a revision of literature on neurochemistry data, up to now found Parkinson's. They study the concentrations alteration of dopamine, acetylcholine, serotonin, noradrenalin, enzymes, neuroaminic acid, metals and amynoacids, concluding on the possible existence of a neurochemistry defect more generalized in the forementioned condition.