James F Nishimuta

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OBJECTIVE The objective of this study was to evaluate photochemical bonding as an approach for adhering live cartilage tissues across a repair interface in a manner that may lead to enhanced integration. DESIGN Photochemical bonding of both meniscal fibrocartilage and articular cartilage was explored using an anionic, hydrophilic phthalocyanine(More)
PURPOSE Although osteoarthritis is widely viewed as a disease of the whole joint, relatively few studies have focused on interactions among joint tissues in joint homeostasis and degeneration. In particular, few studies have examined the effects of the infrapatellar fat pad (IFP) on cartilaginous tissues. The aim of this study was to test the hypothesis(More)
OBJECTIVE This study compared the effects on cartilage and meniscus matrix catabolism and biosynthesis of several adipokines implicated in osteoarthritis (OA). DESIGN Bovine cartilage and meniscus explants were cultured for 1 or 9 days in serum-free medium alone or with 0.02, 0.2, or 2 μg/ml of leptin, visfatin, adiponectin, or resistin. Media were(More)
OBJECTIVE To examine the relative susceptibility of cartilage and meniscus tissues to mechanical injury by applying a single, controlled overload and observing cellular, biochemical, and mechanical changes. DESIGN Cartilage and meniscus tissue explants in radial confinement were subjected to a range of injury by indenting to 40% strain at three different(More)
Aggrecan is an extracellular matrix molecule that contributes to the mechanical properties of articular cartilage and meniscal fibrocartilage, but the abundance and processing of aggrecan in these tissues are different. The objective of this study was to compare patterns of aggrecan processing by chondrocytes and meniscal fibrochondrocytes in tissue(More)
PURPOSE Altered synovial levels of various adipokines (factors secreted by fat as well as other tissues) have been associated with osteoarthritis (OA) onset and progression. However, the metabolic effects of adipokines on joint tissues, in particular the fibrocartilaginous menisci, are not well understood. This study investigated effects of several(More)
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