James F. Brady

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Metabolic activation may be a key step in determining the tissue specificity of carcinogenic nitrosamines. In previous work, we characterized P450IIE1 (an acetone/ethanol-inducible form of cytochrome P-450) as the major enzyme for the metabolic activation of N-nitrosodimethylamine. In this work, we investigated the metabolism of other N-nitrosodialkylamines(More)
Jim has worked over 30 years in the telecommunications and computer industries for GTE, Tandem Computers, Siemens, and currently is the Capacity Planner for the State Of Nevada. At GTE he worked in both Data Center Capacity Planning and Digital Switching Traffic Capacity determination. While at Siemens he obtained EU and US patents for a traffic overload(More)
It has been reported that p.o. administration of diallyl sulfide (DAS), a naturally occurring component of garlic (Allium sativum), inhibits 1,2-dimethylhydrazine-induced colon and liver cancer in rodents. A possible mechanism for this protective effect is inhibition of hepatic activation of the procarcinogen. The effect of DAS on P450IIE1, an isozyme of(More)
Rat nasal cavity is one of the target organs for carcinogenesis induced by N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The present work investigated the metabolism of these nitrosamines by rat nasal microsomes, as well as the possible modulating factors. Microsomes prepared from rat(More)
Many times load testing is dismissed as a waste of time and money because past results didn't conform to real world experience when the application went live. Sometimes it's because the test suite is too narrow but often it is due to the approach used to produce traffic and the way results are interpreted. This discussion focuses on the latter situation(More)
Conventional load-testing tools are based on a fifty-year old time-share computer paradigm where a finite number of users submit requests and respond in a synchronized fashion. Conversely, modern web traffic is essentially asynchronous and driven by an unknown number of users. This difference presents a conundrum for testing the performance of modern web(More)
This is a follow-up to my CMG'12 presentation titled " When Load Testing Large User Population Web Applications the Devil is in the (Virtual) User Details " , [BRAD2012]. During my talk I mentioned that most load tools do not offer a Negative-Exponential distribution timer option, even though it is the logical one to draw think times from when attempting to(More)