James Eason

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Important problems in Computational Medicine exist that can beneet from the implementation of adaptive mesh reenement techniques. Biological systems are so inherently complex that only eecient models running on state of the art hardware can begin to simulate reality. To tackle the complex geometries associated with medical applications we present a general(More)
Small beat-to-beat differences in heart rate are the result of dynamic control of the cardiovascular system by the sympathetic and parasympathetic nervous systems. Heart rate variability (HRV) has been positively correlated with both mental and physical health. While many studies measure HRV under rest conditions, few have measured HRV during stressful(More)
The goal of this modeling research is to provide mechanistic insight into the effect of altered membrane kinetics associated with 5-12 min of acute global ischemia on the upper limit of cardiac vulnerability (ULV) to electric shocks. We simulate electrical activity in a finite-element bidomain model of a 4-mm-thick slice through the canine ventricles that(More)
BACKGROUND Maraviroc treatment for HIV-1 infected patients results in larger CD4(+) T cell rises than are attributable to its antiviral activity alone. We investigated whether this is due to modulation of T cell activation and inflammation. METHODS AND FINDINGS Thirty maraviroc-treated patients from the Maraviroc versus Efavirenz Regimens as Initial(More)
AIMS Studies of arrhythmogenesis during ischemia have focused primarily on reentrant mechanisms manifested on the epicardial surface. The goal of this study was to use a physiologically-accurate model of acute regional ischemia phase 1A to determine the contribution of ischaemia-induced transmural electrophysiological heterogeneities to arrhythmogenesis(More)
BACKGROUND The aim of this study was to investigate the association of gene expression profiles in subcutaneous adipose tissue with weight change in kidney transplant recipients and to gain insights into the underlying mechanisms of weight gain. METHODOLOGY/PRINCIPAL FINDINGS A secondary data analysis was done on a subgroup (n = 26) of existing clinical(More)
In 2014, simultaneous liver kidney transplants (SLK) accounted for 8.2 % of all liver transplants performed in the USA. Prior to introduction of the model of end stage liver disease (MELD) system, SLK accounted for 2.5 % in 2001 and only 1.7 % in 1990. Transplant centers have struggled to balance the moral and ethical aspects of SLK in the setting of organ(More)
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