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Molecular identification of a danger signal that alerts the immune system to dying cells
TLDR
Uric acid stimulates dendritic cell maturation and, when co-injected with antigen in vivo, significantly enhances the generation of responses from CD8+ T cells, and have important implications for vaccines, autoimmunity and inflammation. Expand
Mass spectrometry analysis of HIV‐1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity
TLDR
HIV‐1 Vif is in a dynamic equilibrium between the various oligomers potentially allowing it to interact with other binding partners, and the majority of the intramolecular cross‐links map to regions that have been previously reported to be necessary for viral infectivity. Expand
Biochemical characterization of membrane fractions in murine sperm: Identification of three distinct sub‐types of membrane rafts
TLDR
It is shown that the common practice of characterizing membrane domains as either “raft’ or “non‐raft” oversimplifies the actual biochemical complexity of cellular membranes, which has important implications for scaffolding functions broadly associated with rafts. Expand
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
TLDR
Results suggest that interaction with HLA-DM is driven by a conformational change of the MHC II protein in the region of the α-subunit 310 helix and adjacent extended strand region, and provide a model for the mechanism of DM-mediated peptide exchange. Expand
Complete androgen insensitivity syndrome: effect on human meibomian gland secretions.
TLDR
Sex-related differences exist in the expression of a variety of neutral and, especially, polar fatty acid products in meibomian gland secretions, and these hormonal effects may be mediated through androgen receptors. Expand
Influence of aging on the polar and neutral lipid profiles in human meibomian gland secretions.
OBJECTIVE To determine whether aging is associated with significant alterations in the polar and neutral lipid profiles in human meibomian gland secretions. METHODS Meibomian gland secretions wereExpand
Increased activity of indoleamine 2,3-dioxygenase in serum from acutely infected dengue patients linked to gamma interferon antiviral function.
TLDR
It is demonstrated that IDO plays an important role in the antiviral effect of IFN-gamma against DENV infection in vitro and suggested that it has a role inThe immune response to DENV infections in vivo. Expand
M1 Muscarinic Receptors Inhibit L-type Ca2+ Current and M-Current by Divergent Signal Transduction Cascades
TLDR
The results indicate that L-current is inhibited by a pathway previously shown to control M-current over-recovery after washout of muscarinic agonist, and support a model of M1R-meditated channel modulation that broadens rather than restricts the roles of phospholipids and fatty acids in regulating ion channel activity. Expand
In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses.
TLDR
Data suggest that TIV vaccines are not similar in their ability to activate human T cell responses, and T cell-mediated immunity may offer a more cross-reactive vaccine approach for the prevention of pandemic or epidemic influenza. Expand
Natural Lipid Ligands Associated with Human CD1d Targeted to Different Subcellular Compartments 1
TLDR
The generation of a protease-cleavableCD1d variant with a similar trafficking pattern to wild-type CD1d that can be purified in the absence of detergent and allows the characterization of the naturally associated lipids is reported. Expand
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