James E Talmadge

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Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy.

James E Talmadge
Clinical cancer research : an official journal of…
2007

Cancer immunotherapy has focused on inducing and expanding CTLs and improving the immune recognition of weak antigenic determinants expressed by tumors. However, few positive clinical outcomes have… (More)

History of myeloid-derived suppressor cells

James E Talmadge, Dmitry I Gabrilovich
Nature Reviews Cancer
2013

Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and escape from immunity via T cell suppression. Initially, these myeloid cells were identified as granulocytes or… (More)

Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice.

Yasushi Sawanobori, Satoshi Ueha, +8 authors Kouji Matsushima
Blood
2008

Tumor growth is associated with aberrant myelopoiesis, including the accumulation of CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) that have the potential to promote tumor growth. However,… (More)

AACR centennial series: the biology of cancer metastasis: historical perspective.

James E Talmadge, Isaiah Josh Fidler
Cancer research
2010

Metastasis resistant to therapy is the major cause of death from cancer. Despite almost 200 years of study, the process of tumor metastasis remains controversial. Stephen Paget initially identified… (More)

Evidence for a novel gene associated with low tumor metastatic potential.

Patricia S. Steeg, Generoso Bevilacqua, +4 authors Mark E. Sobel
Journal of the National Cancer Institute
1988

We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems:… (More)

NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice.

Unnur P. Thorgeirsson, Taina Turpeenniemi-Hujanen, +4 authors Lance A. Liotta
Molecular and cellular biology
1985

NIH/3T3 cells transfected with DNA from malignant human tumors produced experimental and spontaneous metastases in nude mice. In contrast, parent or spontaneously transformed NIH/3T3 cells failed to… (More)

Evidence for the clonal origin of spontaneous metastases.

James E Talmadge, Sandra R. Wolman, Isaiah Josh Fidler
Science
1982

A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung… (More)

Classification of current anticancer immunotherapies

Lorenzo Galluzzi, Erika Vacchelli, +83 authors Guido Kroemer
Oncotarget
2014

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and… (More)

Introduction of metastatic heterogeneity by short-term in vivo passage of a cloned transformed cell line.

James E Talmadge, Jean R. Starkey, William C. Davis, Arthur L. Cohen
Journal of supramolecular structure
1979

An experimental system for the study of metastasis has been developed using an epithelioid cell line of hepatic origin which had previously been chemically transformed in vitro. These metastatic… (More)

Enhanced metastatic potential of tumor cells harvested from spontaneous metastases of heterogeneous murine tumors.

James E Talmadge, Isaiah Josh Fidler
Journal of the National Cancer Institute
1982

These studies demonstrated that cells populating spontaneous metastases are, in general, more metastatic than the cells populating the parent neoplasm, thereby providing direct evidence that the… (More)

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