James E. Knake

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Because of the rapid systemic clearance of BCNU (1,3-bis-(2-chloroethyl)-1-nitrosourea), intra-arterial administration should provide a substantial advantage over intravenous administration for the treatment of malignant gliomas. Thirty-six patients were treated with BCNU every 6 to 8 weeks, either by transfemoral catheterization of the internal carotid or(More)
Posttraumatic progressive myelopathy (PTPM) was studied in nine patients and grouped into three categories on the basis of characteristic radiographic findings and response to therapy: (a) myelomalacia with no cystic degeneration, which has poor response to therapy; (b) small cysts, with poor response to therapy; and (c) large cysts, which are effectively(More)
Sixty-four consecutive primary or metastatic brain tumors were reviewed to assess the efficacy of intraoperative sonography for localization, biopsy, and/or drainage. In 12 cases, preoperative CT data were incomplete or confusing, usually due to low-density, non-enhanced areas in which low-grade tumor could not be reliably differentiated from necrosis,(More)
The computed tomographic (CT) and angiographic findings in 14 patients with proved cerebellar hemangioblastomas were reviewed. Although the CT scan was abnormal in all patients who had hemangioblastomas which produced symptoms, angiography was far more sensitive than CT in detecting hemangioblastoma nodules and was usually more specific in characterizing(More)
Nine cases of nearly occluded internal carotid artery (ICA) origins, usually simulating total occlusion, are presented. Correct diagnosis is aided by an awareness of the possibility of near occlusion of the ICA origin and by careful study of selective common carotid angiography with a long imaging sequence and subtraction. Carotid endarterectomy is the(More)
Intraoperative sonography using portable real-time equipment at the dural or brain surface in 16 patients provided accurate localization of a variety of brain lesions for direct dissectional or needle aspiration biopsies as well as for decompression of cysts. The technique has proven to be reliable and rapid, reducing brain exploration in the search for(More)
The cerebral computed tomographic findings in two infants with methylmalonic acidemia and one infant and one adult with propionic acidemia are presented. Pertinent metabolic, clinical, and pathologic features of these genetic disorders of vitamin B12 (cobalamin) and biotin metabolism are reviewed briefly. Computed tomographic abnormalities consist of focal(More)
Real-time sonography during surgery for intraspinal tumors is capable of demonstrating the extent of the tumor, its relation to the spinal cord, and the internal morphology of both the tumor and the cord. Such information is not obtainable intraoperatively by any other imaging method. It is especially valuable when all or a part of the tumor is anterior to(More)
Compromise of blood flow in the vertebral arteries associated with head rotation is generally considered an uncommon cause of vertebrobasilar insufficiency. It can occur at virtually any level of the cervical spine. We present two cases of transient total occlusion of the left vertebral artery at the atlantoaxial joint during head rotation to the right. In(More)