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All material appearing in this report is in the public domain and may be reproduced or copied without permission: citation as to source, however, is appreciated. v Digestive diseases include a wide spectrum of disorders affecting the oropharynx and alimentary canal, liver and biliary system, and pancreas. These disorders have diverse causes, including(More)
BACKGROUND Benign reductions in neutrophil counts may be more common at certain ages and in certain ethnic groups and may be affected by sex and smoking status. OBJECTIVE To determine differences in neutrophil counts in the U.S. population according to ethnicity, age, sex, and smoking status. DESIGN Population-based, cross-sectional study. SETTING(More)
UNLABELLED Higher coffee consumption has been associated inversely with the incidence of chronic liver disease in population studies. We examined the relationship of coffee consumption with liver disease progression in individuals with advanced hepatitis C-related liver disease. Baseline coffee and tea intake were assessed in 766 participants of the(More)
Influence of delayed isotopic equil-ibration in urine on the accuracy of the 2 H2 18 O method in the elderly.pic determination of total energy expenditure (TEE) by the doubly labeled water (DLW) method may be affected by urine retention in the elderly. The isotopic enrichments in urine and plasma sampled simultaneously 4 h post-DLW dose were compared in a(More)
BACKGROUND & AIMS High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS Patients (n=885) from the lead-in phase of the Hepatitis C Antiviral Long-Term(More)
BACKGROUND Genetic variation in IL28B and other factors are associated with sustained virological response (SVR) after pegylated-interferon/ribavirin treatment for chronic hepatitis C (CHC). Using data from the HALT-C Trial, we developed a model to predict a patient's probability of SVR based on IL28B genotype and clinical variables. METHODS HALT-C(More)
Despite recent interest in water intake, few data are available on water metabolism in adults. To determine the average and range of usual water intake, urine output, and total body water, we administered 2H oxide to 458 noninstitutionalized 40- to 79-yr-old adults living in temperate climates. Urine was collected in a subset of individuals (n = 280) to(More)
BACKGROUND The incidence of acute liver failure or serious liver injury in diabetic patients is needed to evaluate the safety of hypoglycemic drug therapy. METHODS We conducted a retrospective cohort study of 5 health maintenance organizations. Study patients were 171,264 health plan members 19 years or older when they received oral hypoglycemic drugs or(More)
Diabetes mellitus is an interminable disease that forces excessively high human, social and financial expenses for a nation. Additionally, minimizing its commonness rate and in addition its excessive and risky confusions requires viable administration. Diabetes administration depends on close participation between the patient and health awareness experts.(More)
BACKGROUND Very little is known about the longitudinal changes in energy requirements in late life. The purposes of this study were to: (1) determine the energy requirements in late life and how they changed during a 7 year time-span, (2) determine whether changes in fat free mass (FFM) were related to changes in resting metabolic rate (RMR), and (3)(More)