James E. Duggan

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Alzheimer's disease (AD) is the major cause of dementia in the world. Although the entorhinal cortex and hippocampal complex are best known as the sites of early pathology in AD, increasing evidence shows that the eye, particularly the retina, is also affected. The AD-related changes in the retina are associated with degeneration and loss of neurons,(More)
Nerve cell death is the key event in all neurodegenerative disorders, with apoptosis and necrosis being central to both acute and chronic degenerative processes. However, until now, it has not been possible to study these dynamically and in real time. In this study, we use spectrally distinct, well-recognised fluorescent cell death markers to enable the(More)
Visual information is sent from the retina to central visual targets through the optic nerve formed of retinal ganglion cells' (RGCs) axons. In rodents, the superior colliculus (SC) is the major site of termination of retinal axons, whilst in primates and felines, it is the lateral geniculate nucleus (LGN). Glaucoma is a progressive optic neuropathy(More)
The axons of retinal ganglion cells form fascicles that leave the globe through pores in the optic nerve head formed by beams of glia and collagen. In eyes obtained at time of autopsy of 17 normal subjects of various ages, these pores were counted and measured in the lamina choroidalis and lamina scleralis of the nerve heads. The number of pores at the(More)
We studied six operating department assistants performing simulated cricoid pressure on a model of the larynx with the arm either flexed to 90 degrees (flexed position) or fully extended with the elbow locked (extended position). Subjects were asked to maintain forces of 20, 30 and 40 Newtons (N) for a target time of 20 min. Subjects rated pain during each(More)
Studies of the empirical relationship between income and mortality often rely on data aggregated by geographic areas and broad population groups and do not distinguish disabled and nondisabled persons. We investigate the relationship between individual mortality and lifetime income with a large micro data base of current and former retired workers. Logit(More)
Foreword In honor of the Bicentennial of the United States Constitution, OTA is conducting a study of Science, Technology, and the Constitution. At the request of the Committee on the Judiciary of the House of Representatives, and its Subcommittee on Courts, Civil Liberties and the Administration of Justice, OTA is examining ways in which continuing(More)
Sunscreens are perceived as gooey, sticky, uncomfortable products that are difficult to apply and distasteful to wear. This accounts for dismal compliance when dermatologists ask patients to use daily sunscreen. Since the time delay between accumulated sun exposure and skin cancer can be more than 20 years, patients do not receive a short-term benefit from(More)
Section 3, stipulate that " a quorum for a business meeting of the Association shall consist of fifty members registered at that meeting. " The Chair observes that there is a quorum. ¶2 The Chair would now like to introduce those present at the head table. Adoption of the Standing Rules ¶3 The Rules of Conduct for the AALL Business Meeting are on the table(More)
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