James Dixon

Learn More
Regulation of transforming growth factor-beta (TGF-beta) signaling is critical in vertebrate development, as several members of the TGF-beta family have been shown to act as morphogens, controlling a variety of cell fate decisions depending on concentration. Little is known about the role of intracellular regulation of the TGF-beta pathway in development.(More)
AIMS Long-QT syndromes (LQTS) are mostly autosomal-dominant congenital disorders associated with a 1:1000 mutation frequency, cardiac arrest, and sudden death. We sought to use cardiomyocytes derived from human-induced pluripotency stem cells (hiPSCs) as an in vitro model to develop and evaluate gene-based therapeutics for the treatment of LQTS. METHODS(More)
BACKGROUND Breast cancer is a disease characterised by both genetic and epigenetic alterations. Epigenetic silencing of tumour suppressor genes is an early event in breast carcinogenesis and reversion of gene silencing by epigenetic reprogramming can provide clues to the mechanisms responsible for tumour initiation and progression. In this study we apply(More)
Little is known about extrinsic signals required for the advancement of motor neuron (MN) axons, which extend over long distances in the periphery to form precise connections with target muscles. Here we present that Rnf165 (Arkadia-like; Arkadia2; Ark2C) is expressed specifically in the nervous system and that its loss in mice causes motor innervation(More)
  • Barbara C Phillips-Farley, Phillips-Farley, Barbara C, Barbara C Phillips Farley, Lowell Cross, D M A Thesis +12 others
  • 2015
founded in 1966 with a grant from The Rockefeller Foundation, initially performed many works of music which had never been done in the Iowa City area. Through its championing of the new music of faculty and student composers, it invigorated the School of Music's composition offerings. Its fine performances brought new music to many locations in Iowa and(More)
Reprogramming of somatic cells to pluripotent cells promises to transform regenerative medicine. Recently many groups have achieved direct reprogramming of somatic cells by forced expression of defined factors using multiple viral vectors. However , such induced pluripotent stem (iPS) cells contain a number of viral vector integrations, any one of which(More)
family of signalling molecules with key functions in nervous system development and function. They regulate cell survival, axon guidance and targeting, synaptic formation and function, learning and memory. Deficient NGF function occurs in Alzheimer's disease and alterations in BDNF function underlie psychiatric and cognitive disorders such as epilepsy,(More)
The enteric nervous system (ENS) is a complex network of neurons and glia within the gut wall which originate from neural crest cells. Self-renewing, multipotential ENS progenitors have been isolated from the gut of foetal as well as adult rodents, however , the identity of the ENS progenitor and the regulation of its neurogenic potential invivo, are(More)
mordial germ cells (PGCs) in mice and axolotls, we propose that the deletion of Nanog in species often employed as experimental models, such as frogs and teleosts (Zebrafish; Danio rerio), has been compensated by the evolution of predetermined germ cells in these organisms. Our data highlights Nanog as a major component of the gene regulatory network that(More)