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Due to its potential to greatly accelerate a wide variety of applications, reconfigurable computing has become a subject of a great deal of research. By mapping the compute-intensive sections of an application to reconfigurable hardware, custom computing systems exhibit significant speedups over traditional microprocessors. However, this potential(More)
Harvard Community Health Plan and the Center for Intelligent Information Retrieval are developing tools to support automated quality fo care measurement from clinical text data. A statistically based text classification system uses semantic features in computerized encounter notes to identify acute exacerbations of asthma. Individual encounter notes are(More)
Custom computing systems exhibit significant speedups over traditional microprocessors by mapping compute-intensive sections of a program to reconfigurable logic [Hauck98]. However, the number and frequency of these hardware-mapped sections of code are limited by the requirement that the speedups provided must outweigh the considerable cost of(More)
Custom computing systems exhibit significant speedups over traditional microprocessors by mapping compute-intensive sections of a program to reconfigurable logic [Hauck98]. However, the number and frequency of these hardware-mapped sections of code are limited by the requirement that the speedups provided must outweigh the considerable cost of(More)
Cells must make appropriate fate decisions within a complex and dynamic environment. In vitro studies indicate that the cytoskeleton acts as an integrative platform for this environmental input. External signals regulate cytoskeletal dynamics and the cytoskeleton reciprocally modulates signal transduction. However, in vivo studies linking(More)
The delimitation of cryptic species and lineages is a common finding of phylogenetic studies. Species previously considered to be of low conservation priority might actually be comprised of multiple lineages with substantially smaller geographic ranges and smaller populations that are of much greater conservation concern and that require different(More)
The branchiopod crustacean Triops longicaudatus has paddlelike thoracic appendages with few joints and multiple marginal lobes. Here, we explore the degree to which the Triops limb is patterned by the same network of genes known to pattern the uniramous, multi-jointed insect appendage. Insect leg patterning proceeds through a process of subdividing the leg(More)
Cell-matrix adhesion strongly influences developmental signaling. Resulting impacts on cell migration and tissue morphogenesis are well characterized. However, the in vivo impact of adhesion on fate induction remains ambiguous. Here, we employ the invertebrate chordate Ciona intestinalis to delineate an essential in vivo role for matrix adhesion in heart(More)