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Hypertext systems allow flexible access to topics of information, but this flexibility has disadvantages. Users often become lost or overwhelmed by choices. An adaptive hypertext system can overcome these disadvantages by recommending information to users based on their specific information needs and preferences. Simple associative matrices provide an(More)
Linear relationships between synaptic activity and hemodynamic responses are critically dependent on functional signal etiology and paradigm. To investigate these relationships, we simultaneously measured local field potentials (FPs) and optical intrinsic signals in rat somatosensory cortex while delivering a small number of electrical pulses to the hindpaw(More)
Hardwired ASICs - 50X more efficient than programmable processors - sacrifice programmability to meet the efficiency requirements of demanding embedded systems. Programmable processors use energy mostly to supply instructions and data to the arithmetic units, and several techniques can reduce instruction- and data-supply energy costs. Using these techniques(More)
As in Clark and Prout's classic work, we identify three phases of generalised convulsive status epilepticus, which we call impending, established, and subtle. We review physiological and subcellular changes that might play a part in the transition from single seizures to status epilepticus and in the development of time-dependent pharmacoresistance. We(More)
Functional differentiation is orchestrated by precise growth-regulatory controls conveyed by the tissue microenvironment. Cues from laminin 111 (LN1) lower transcription and suppress mammary epithelial cell growth in culture, but how LN1 induces quiescence is unknown. Recent literature points to involvement of nuclear β-actin in transcriptional regulation.(More)
We review recent advances in our understanding and treatment of status epilepticus (SE). Repeated seizures cause an internalization of gamma-aminobutyric acid (GABA)(A) receptors, together with a movement of N-methyl-d-aspartate (NMDA) receptors to the synapse. As a result, the response of experimental SE to treatment with GABAergic drugs (but not with NMDA(More)
OBJECTIVE This study investigates the generators of alpha coma activity and the probable cerebral pathways involved in alpha coma patients. METHODS This study uses independent component analysis (ICA) and dipole fitting algorithm to locate the cerebral generators in alpha coma and normal alpha rhythms. RESULTS Distinct distributions of the source(More)
The Picture Archiving and Communication System (PACS) market has been transformed by disruptive innovations from the information technology industry. The cost of storage alone has dropped by a factor of 100 within the past 10 years. Improvements in display, processing, and networking have likewise enabled PACS to be a capable replacement for film. The(More)
Status epilepticus (SE) describes an enduring epileptic state during which seizures are unremitting and tend to be self-perpetuating. We describe the clinical phases of generalized convulsive SE, impending SE, established SE, and subtle SE. We discuss the physiological and biochemical cascades which characterize self-sustaining SE (SSSE) in animal models.(More)