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Computer based speech training systems aim to provide the client with customised tools for improving articulation based on audiovisual stimuli and feedback. They require the integration of various components of speech technology, such as speech recognition and transcription tools, and a database management system which supports multiple on-the-fly(More)
We describe an unusual ASR application: recognition of command words from severely dysarthric speakers, who have poor control of their articulators. The goal is to allow these clients to control assistive technology by voice. While this is a small vocabulary, speaker-dependent, isolated-word application, the speech material is more variable than normal, and(More)
This study reports on the development of an automated isolated-word intelligibility metric system designed to improve the scoring consistency and reliability of the Frenchay Dysarthria Assessment Test (FDA).The proposed intelligibility measurements are based on the probabilistic likelihood scores derived from the forced alignment of the dysarthric speech to(More)
This paper describes a new formulation of a polynomial sequence kernel based on dynamic time warping (DTW) for support vector machine (SVM) classification of isolated words given very sparse training data. The words are uttered by dysarthric speakers who suffer from debilitating neurological conditions that make the collection of speech samples a(More)
  • Rebecca A Dent, Geoffrey J Lindeman, Mark Clemons, Hans Wildiers, Arlene Chan, Nicole J McCarthy +4 others
  • 2013
This Phase I study evaluated the safety, tolerability and efficacy of olaparib, a potent oral poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with paclitaxel in patients with metastatic triple-negative breast cancer (mTNBC). Eligible patients who had received ≤1 prior cytotoxic regimen for mTNBC were treated with olaparib 200 mg bid(More)
BACKGROUND A randomized, unmasked, multicenter study was conducted to evaluate the rate of pruritus reduction and improvement in clinical scoring by cyclosporine A (5 mg/kg orally, once daily for 28 days) either alone (n = 25 dogs) or with concurrent prednisolone (1 mg/kg once daily for 7 days, followed by alternate dosing for 14 days; n = 23 dogs) for the(More)
This paper describes a multimedia multimodal information access subsystem (MIAS) for digital audiovisual documents, typically presented in streaming media format. The system is designed to provide both professional and general users with entry points into video documents that are relevant to their information needs. In this work, we focus on the information(More)
  • Cassan N Pulaski, John B Malone, Catherine Bourguinat, Roger Prichard, Timothy Geary, Danielle Ward +9 others
  • 2014
Strains of Dirofilaria immitis suspected of lack of efficacy (LOE) to macrocyclic lactone (ML) preventive drugs have been increasingly reported in dogs by practicing veterinarians since 2005 in the Lower Mississippi Delta region. If proven, and not controlled in the early stages, the emergence of ML drug resistance threatens to become a widespread problem(More)