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Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity with respect to 75 other proteins of various types(More)
MOTIVATION Identifying drug-drug interactions (DDIs) is a critical process in drug administration and drug development. Clinical support tools often provide comprehensive lists of DDIs, but they usually lack the supporting scientific evidences and different tools can return inconsistent results. In this article, we propose a novel approach that integrates(More)
Interest continues to build around the early application of patient selection markers to prospectively identify patients likely to show clinical benefit from cancer therapies. Hypothesis generation and clinical strategies often begin at the preclinical stage where responder and nonresponder tumor cell lines are first identified and characterized. In the(More)
Motivation: Identifying drug-drug interactions is a critical process in drug administration and drug development. Clinical support tools often provide comprehensive lists of drug-drug interactions, but they usually lack the supporting scientific evidences and different tools can return inconsistent results. In this paper, we propose a novel approach that(More)
As the scale of available on-line data grows ever larger, individuals and businesses must cope with increasing complexity in decision-making processes which utilize large volumes of unstructured, semi-structured and/or structured data to satisfy multiple, interrelated information needs which contribute to an overall decision. Traditional decision support(More)
— A number of bandwidth reservation schemes have been proposed for multi-channel ring, generally classified as centralized and distributed. Besides simulation results, the existing analytical models address only the blocking probability and achievable throughput of such schemes. However, in determining the properties and advantages of each reservation(More)
Radio Frequency Identification (RFID) has been adopted to track items in supply chain, healthcare, and manufacturing applications. Hospitals and factories, however, are difficult environments for radiowave propagation. Cinder block walls with steel rebar, metal obstructions, and RF noise present significant obstacles to RFID system performance. Tagging(More)