James Cai

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MOTIVATION Identifying drug-drug interactions (DDIs) is a critical process in drug administration and drug development. Clinical support tools often provide comprehensive lists of DDIs, but they usually lack the supporting scientific evidences and different tools can return inconsistent results. In this article, we propose a novel approach that integrates(More)
Motivation: Identifying drug-drug interactions is a critical process in drug administration and drug development. Clinical support tools often provide comprehensive lists of drug-drug interactions, but they usually lack the supporting scientific evidences and different tools can return inconsistent results. In this paper, we propose a novel approach that(More)
— A number of bandwidth reservation schemes have been proposed for multi-channel ring, generally classified as centralized and distributed. Besides simulation results, the existing analytical models address only the blocking probability and achievable throughput of such schemes. However, in determining the properties and advantages of each reservation(More)
BACKGROUND With the large amount of pharmacological and biological knowledge available in literature, finding novel drug indications for existing drugs using in silico approaches has become increasingly feasible. Typical literature-based approaches generate new hypotheses in the form of protein-protein interactions networks by means of linking concepts(More)
Medical vocabulary databases are vital components of electronic medical record (EMR) systems. While their performance and efficiency has been extensively explored by many authors, few have dealt with the maintenance of their semantic integrity. Clinicians' preference for an optimistic system has introduced a need for monitoring and filtering proposed(More)
Identifying drug target candidates is an important task for early development throughout the drug discovery process. This process is supported by the development of new high-throughput technologies that enable better understanding of disease mechanism. It becomes critical to facilitate effective analysis of the large amount of biological data. However, with(More)