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Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity with respect to 75 other proteins of various types(More)
MOTIVATION Identifying drug-drug interactions (DDIs) is a critical process in drug administration and drug development. Clinical support tools often provide comprehensive lists of DDIs, but they usually lack the supporting scientific evidences and different tools can return inconsistent results. In this article, we propose a novel approach that integrates(More)
Interest continues to build around the early application of patient selection markers to prospectively identify patients likely to show clinical benefit from cancer therapies. Hypothesis generation and clinical strategies often begin at the preclinical stage where responder and nonresponder tumor cell lines are first identified and characterized. In the(More)
As a powerful research tool, siRNA's therapeutic and target validation utility with leukemia cells and long-term gene knockdown is severely restricted by the lack of omnipotent, safe, stable, and convenient delivery. Here, we detail our discovery of siRNA-containing lipid nanoparticles (LNPs) able to effectively transfect several leukemia and(More)
Motivation: Identifying drug-drug interactions is a critical process in drug administration and drug development. Clinical support tools often provide comprehensive lists of drug-drug interactions, but they usually lack the supporting scientific evidences and different tools can return inconsistent results. In this paper, we propose a novel approach that(More)
BACKGROUND With the large amount of pharmacological and biological knowledge available in literature, finding novel drug indications for existing drugs using in silico approaches has become increasingly feasible. Typical literature-based approaches generate new hypotheses in the form of protein-protein interactions networks by means of linking concepts(More)
As the scale of available on-line data grows ever larger, individuals and businesses must cope with increasing complexity in decision-making processes which utilize large volumes of unstructured, semi-structured and/or structured data to satisfy multiple, interrelated information needs which contribute to an overall decision. Traditional decision support(More)