• Publications
  • Influence
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis
Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated byExpand
  • 15
  • 2
  • PDF
Repo-Man/PP1 regulates heterochromatin formation in interphase
Repo-Man is a protein phosphatase 1 (PP1) targeting subunit that regulates mitotic progression and chromatin remodelling. After mitosis, Repo-Man/PP1 remains associated with chromatin but itsExpand
  • 27
  • 1
  • PDF
Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2
Abstract Blood dendritic cell antigen 2 (BDCA-2) is a C-type lectin found on the surface of plasmacytoid dendritic cells. It functions as a glycan-binding receptor that downregulates the productionExpand
  • 3
Repo-Man / PP 1 regulates heterochromatin formation 1 in interphase
General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing theseExpand
Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei
Significance The African trypanosome Trypanosoma brucei expresses a single variant surface glycoprotein (VSG) gene from one of multiple VSG expression sites (ESs) in a stringent monoallelic fashion.Expand
  • 1
  • PDF
Deposited in DRO : 25 January 2017 Version of attached le : Published Version Peer-review status of attached
Citation for published item: Castro, Ines and Budzak, James and Di Giacinto, Maria L. and Ligammari, Lorena and Gokhan, Ezgi and Spanos, Christos and Moralli, Daniela and Richardson, Christine and deExpand