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Two eukaryotic pathways for processing double-strand breaks (DSBs) as crossovers have been described, one dependent on the MutL homologs Mlh1 and Mlh3, and the other on the structure-specific endonuclease Mus81. Mammalian MUS81 has been implicated in maintenance of genomic stability in somatic cells; however, little is known about its role during meiosis.(More)
Evaluating the likelihood function of parameters in highly-structured population genetic models from extant deoxyribonucleic acid (DNA) sequences is computationally prohibitive. In such cases, one may approximately infer the parameters from summary statistics of the data such as the site-frequency-spectrum (SFS) or its linear combinations. Such methods are(More)
The Menpo Project, hosted at http://www.menpo.io, is a BSD-licensed software platform providing a complete and comprehensive solution for annotating, building, fitting and evaluating deformable visual models from image data. Menpo is a powerful and flexible cross-platform framework written in Python that works on Linux, OS X and Windows. Menpo has been(More)
Bioelectrochemical systems (BESs) employing mixed microbial communities as biocatalysts are gaining importance as potential renewable energy, bioremediation, or biosensing devices. While we are beginning to understand how individual microbial species interact with an electrode as electron donor, little is known about the interactions between different(More)
Shewanella oneidensis is a target of extensive research in the fields of bioelectrochemical systems and bioremediation because of its versatile metabolic capabilities, especially with regard to respiration with extracellular electron acceptors. The physiological activity of S. oneidensis to respire at electrodes is of great interest, but the growth(More)
The functions of several SOS regulated genes in Escherichia coli are still unknown, including dinQ. In this work we characterize dinQ and two small RNAs, agrA and agrB, with antisense complementarity to dinQ. Northern analysis revealed five dinQ transcripts, but only one transcript (+44) is actively translated. The +44 dinQ transcript translates into a(More)
BACKGROUND Previous literature suggests that those with reading disability (RD) have more pronounced deficits during semantic processing in reading as compared to listening comprehension. This discrepancy has been supported by recent neuroimaging studies showing abnormal activity in RD during semantic processing in the visual but not in the auditory(More)
Due to the logographic nature of the writing system, learning to read Chinese places heavy demands on encoding of orthographic forms through rote memorization. Moreover, phonology has to often be retrieved from memory during reading because of the inconsistent mapping between characters and their pronunciations. Using optimized voxel-based morphometry, we(More)
We present Large Scale Facial Model (LSFM) — a 3D Morphable Model (3DMM) automatically constructed from 9,663 distinct facial identities. To the best of our knowledge LSFM is the largest-scale Morphable Model ever constructed , containing statistical information from a huge variety of the human population. To build such a large model we introduce a novel(More)