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We study the daily and intradaily cross-sectional relation between stock returns and the trading of institutional and individual investors in Nasdaq 100 securities. Based on the previous day's stock return, the top performing decile of securities is 23.9% more likely to be bought in net by institutions (and sold by individuals) than those in the bottom(More)
Two eukaryotic pathways for processing double-strand breaks (DSBs) as crossovers have been described, one dependent on the MutL homologs Mlh1 and Mlh3, and the other on the structure-specific endonuclease Mus81. Mammalian MUS81 has been implicated in maintenance of genomic stability in somatic cells; however, little is known about its role during meiosis.(More)
We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patients into 16 groups. Five of these groups defined new AML(More)
Evaluating the likelihood function of parameters in highly-structured population genetic models from extant deoxyribonucleic acid (DNA) sequences is computationally prohibitive. In such cases, one may approximately infer the parameters from summary statistics of the data such as the site-frequency-spectrum (SFS) or its linear combinations. Such methods are(More)
The Menpo Project, hosted at http://www.menpo.io, is a BSD-licensed software platform providing a complete and comprehensive solution for annotating, building, fitting and evaluating deformable visual models from image data. Menpo is a powerful and flexible cross-platform framework written in Python that works on Linux, OS X and Windows. Menpo has been(More)
We present Large Scale Facial Model (LSFM) - a 3D Morphable Model (3DMM) automatically constructed from 9,663 distinct facial identities. To the best of our knowledge LSFM is the largest-scale Morphable Model ever constructed, containing statistical information from a huge variety of the human population. To build such a large model we introduce a novel(More)
BACKGROUND Despite comprehensive investigation, the Escherichia coli SOS response system is not yet fully understood. We have applied custom designed whole genome tiling arrays to measure UV invoked transcriptional changes in E. coli. This study provides a more complete insight into the transcriptome and the UV irradiation response of this microorganism. (More)
Recognition and interference of a nontarget language (Russian) during production in a target language (English) were tested in Russian-English bilinguals using eye movements and picture naming. In Experiment 1, Russian words drew more eye movements and delayed English naming to a greater extent than control nonwords and English translation equivalents. In(More)
The functions of several SOS regulated genes in Escherichia coli are still unknown, including dinQ. In this work we characterize dinQ and two small RNAs, agrA and agrB, with antisense complementarity to dinQ. Northern analysis revealed five dinQ transcripts, but only one transcript (+44) is actively translated. The +44 dinQ transcript translates into a(More)
Establishing inter-mesh dense correspondence is a key step in the process of constructing Morphable Models. The most successful approaches to date reduce this 3D correspondence problem to a 2D image morphing one by applying an interpolant in UV space - a space in which the manifold of the face is flattened into a contiguous 2D atlas. Contiguous UV spaces(More)