In confirmation of Shirai's observation, we find that transplantable mouse tumors grow actively when inoculated into the brains of rats, guinea pigs, and pigeons, whereas subcutaneous or intramuscular grafts in the same animals fail. This growth of foreign tissue in the brain, however, takes place only when the grafted material lies entirely in the brain… (More)
The direct inoculation of a sarcoma of the fowl into the developing chick embryo or its membranes has yielded growths in many cases. The best results have been obtained with grafts of the living tumor tissue, but, as in the adult, growths can be engendered with dried tissue or with the Berkefeld filtrate of a tumor extract. When living tumor tissue is used,… (More)
Previous observations have tended to show conclusively that tissues cannot be transplanted from one species to another, even though these be closely related. Two theories have been brought forward to explain this failure in heteroplastic grafting. The two schools are still at variance and neither has been able to produce evidence conclusive enough to… (More)
Inoculation of the Jensen rat sarcoma into the developing chick embryo gives a rapidly growing tumor at the site of inoculation, whether in the membranes or in the body of the chick itself. These tumors by transfer from embryo to embryo can be kept going for as long as forty-six days, and perhaps indefinitely in the foreign species. The rat cells show no… (More)
A causative agent has been separated from three chicken tumors of very different sort, namely a spindle-celled sarcoma, an osteochondrosarcoma, and a spindle-celled sarcoma peculiarly fissured by blood sinuses. This was accomplished after the tumors had been transplanted repeatedly and their malignancy enhanced. Each of the tumor-producing agents is a… (More)
In a previous: communication we reported the existence of a relationship between the resistant state to transplantable tumors in mice and a lymphocytic crisis in the circulating blood. We further demonstrated that by a previous destruction of the lymphoid tissue of these animals with x-ray a potentially resistant animal was rendered susceptible to cancer… (More)
Variations are described which have from time to time occurred in the structure and behavior of a transplantable, spindle-celled sarcoma of the fowl, a growth caused, as elsewhere shown, by a filterable agent. Of late the growth has frequently given rise to fatal hemorrhages from its substance. In some of the recent, rapidly growing tumors the cells have… (More)
The lymphoid organs of mice show definite changes after cancer inoculation. In immune mice there is a tendency towards a lymphoid hyperplasia, while in susceptible mice more or less marked depletion of the lymphoid tissue takes place. These changes are evident at the end of the 3rd week after cancer inoculation.