Homoclinic snaking refers to the bifurcation structure of symmetric localised roll patterns that are often found to lie on two sinusoidal " snaking " bifurcation curves, which are connected by an infinite number of " rung " segments along which asymmetric localised rolls of various widths exist. The envelopes of all these structures have a unique maximum… (More)
During recent years N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers have been developed as targetable drug carriers. These soluble synthetic polymers are internalized by cells by pinocytosis and they can be tailor-made to include peptidyl side-chains degradable intracellularly by specific lysosomal enzymes. Thus they provide the opportunity fo achieve… (More)
DBA2 mice were inoculated i.p. with 10(5)L1210 cells. Animals subsequently treated with daunomycin (single i.p. dose, 0.25-5.0 mg kg-1) all died. The maximum increase in mean survival time observed was approximately 135%. Animals treated with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers conjugated to daunomycin (DNM) showed a significant increase in… (More)
Pinocytic uptake of 125I-labeled bovine serum albumin by 17.5-day rat visceral yolk sac cultured in vitro has been examined. Uptake was followed by intracellular digestion and, after an initial period, the content of radioactivity in the tissue itself remained constant during the incubation. Radiolabel was returned to the culture medium predominantly as… (More)
to thank all UN-Water Members and Partners for their feedback and revisions during the review process. The UN-Water Task Force on Water Security would like to thank Harriet Bigas, UNU-INWEH for leading the coordination and development of the Brief, and Stéfanie Neno and James Morgan, FAO for facilitating the design and layout of the Brief.