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Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in immune-naïve infants and young children, accounting for 18% of all deaths before five years of age. Clinical manifestations of severe falciparum malaria vary according to(More)
Chemokines regulate the host immune response to a variety of infectious pathogens. Since the role of chemokines in regulating host immunity in children with Plasmodium falciparum malaria has not previously been reported, circulating levels of beta-chemokines (MIP-1alpha, MIP-1beta, and RANTES) and their respective transcriptional profiles in ex vivo(More)
The authors conducted a Monte Carlo simulation of 8 statistical tests for comparing dependent zero-order correlations. In particular, they evaluated the Type I error rates and power of a number of test statistics for sample sizes (Ns) of 20, 50, 100, and 300 under 3 different population distributions (normal, uniform, and exponential). For the Type I error(More)
It is well known that when data are nonnormally distributed, a test of the significance of Pearson's r may inflate Type I error rates and reduce power. Statistics textbooks and the simulation literature provide several alternatives to Pearson's correlation. However, the relative performance of these alternatives has been unclear. Two simulation studies were(More)
This study examined the gender invariance of the 13-item Sense of Coherence (SOC) scale. Confirmatory factor analyses indicated that a single factor model with one pair of correlated errors fit the data well. Invariance testing indicated that the scale is both congeneric and tau equivalent, meaning that a single latent SOC construct holds equally well for(More)
A meta-analysis was conducted to investigate the association between sensation seeking and alcohol use. Analysis of 61 studies revealed a small to moderate size, heterogeneous effect (mean weighted r=.263) between alcohol use and sensation seeking total scale scores. Analysis of the four sensation seeking components indicated that disinhibition was most(More)
The present study examined the effects of substance use history and depressive symptomatology on the cognitive functioning of 149 male and 72 female dually diagnosed inpatients. Logistic regression models examined the effects of life-time alcohol and cocaine use, previous month's alcohol and cocaine use and depression on abstract reasoning as assessed by(More)
The dimensional characteristics of the SCL-90-R were assessed for both male and female dually diagnosed inpatients. Subjects included 402 males and 227 females who presented with concurrent psychiatric and substance use disorders at a private psychiatric hospital. Confirmatory factor analyses resulted in the rejection of four previous measurement models for(More)
A random-effects meta-analysis was conducted to examine the association between ecstasy use and risky sexual behavior. Analysis of 17 studies revealed a small to moderate sized effect (mean weighted r=0.211, 95% CI: 0.085-0.336). Random-effects homogeneity testing was non-significant, thus formal moderator analyses were not performed. Moreover, numerical(More)