Douglas J. Perkins4
Kim May3
Prakasha Kempaiah2
Tom Were2
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Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in immune-naïve infants and young children, accounting for 18% of all deaths before five years of age. Clinical manifestations of severe falciparum malaria vary according to(More)
Chemokines regulate the host immune response to a variety of infectious pathogens. Since the role of chemokines in regulating host immunity in children with Plasmodium falciparum malaria has not previously been reported, circulating levels of beta-chemokines (MIP-1alpha, MIP-1beta, and RANTES) and their respective transcriptional profiles in ex vivo(More)
This study examined the gender invariance of the 13-item Sense of Coherence (SOC) scale. Confirmatory factor analyses indicated that a single factor model with one pair of correlated errors fit the data well. Invariance testing indicated that the scale is both congeneric and tau equivalent, meaning that a single latent SOC construct holds equally well for(More)
The authors conducted a Monte Carlo simulation of 8 statistical tests for comparing dependent zero-order correlations. In particular, they evaluated the Type I error rates and power of a number of test statistics for sample sizes (Ns) of 20, 50, 100, and 300 under 3 different population distributions (normal, uniform, and exponential). For the Type I error(More)
It is well known that when data are nonnormally distributed, a test of the significance of Pearson's r may inflate Type I error rates and reduce power. Statistics textbooks and the simulation literature provide several alternatives to Pearson's correlation. However, the relative performance of these alternatives has been unclear. Two simulation studies were(More)
  • Ariel L. Rivas, Folorunso O. Fasina, Almira L. Hoogesteyn, Steven N. Konah, José L. Febles, Douglas J. Perkins +4 others
  • 2012
BACKGROUND To effectively control the geographical dissemination of infectious diseases, their properties need to be determined. To test that rapid microbial dispersal requires not only susceptible hosts but also a pre-existing, connecting network, we explored constructs meant to reveal the network properties associated with disease spread, which included(More)
A random-effects meta-analysis was conducted to examine the association between ecstasy use and risky sexual behavior. Analysis of 17 studies revealed a small to moderate sized effect (mean weighted r=0.211, 95% CI: 0.085-0.336). Random-effects homogeneity testing was non-significant, thus formal moderator analyses were not performed. Moreover, numerical(More)
A meta-analysis was conducted to investigate the association between sensation seeking and alcohol use. Analysis of 61 studies revealed a small to moderate size, heterogeneous effect (mean weighted r=.263) between alcohol use and sensation seeking total scale scores. Analysis of the four sensation seeking components indicated that disinhibition was most(More)
BACKGROUND Improved characterization of infectious disease dynamics is required. To that end, three-dimensional (3D) data analysis of feedback-like processes may be considered. METHODS To detect infectious disease data patterns, a systems biology (SB) and evolutionary biology (EB) approach was evaluated, which utilizes leukocyte data structures designed(More)