James B Gibson

Learn More
A battery of psychomotor tasks and physiological measures was administered to 206 pairs of twins before alcohol and then three times at hourly intervals after they ingested a standard dose of ethanol (0.75 g/kg body weight). Repeat measurements were obtained for 4l of these pairs on a second occasion. Performance on motor coordination, standing steadi-ness,(More)
Blood alcohol measurements were obtained for 206 pairs of twins who had ingested a standard dose of alcohol (0.75g/kg body weight) and repeat measurements were obtained for 40 of these pairs on a second occasion. The repeatability of the peak blood alcohot concentration (BAC) was 0.66, that of the rate of elimination was 0.39, and that of the time to peak(More)
Despite restricted ingestion of lactose, patients with galactose-1-phosphate uridyltransferase deficiency have raised concentrations of galactose metabolites in blood and urine. Endogenous production of galactose may underlie this phenomenon. Using isotopically labelled galactose in a continuous intravenous infusion, we employed the steady-state flux method(More)
A study of lung function in 203 twin pairs aged 18-34 years living in Sydney detected significant genetic variation in females and males. There was no evidence of family environmental effects in either sex and most of the repeatable variation in females was heritable. However, there was evidence for systematic environmental differences between males(More)
It Is a commonplace observation that some people are greatly affected by even small doses of alcohol while others seem relatively tolerant to even large doses. How much of this variation in susceptibility to intoxication is genetically deter-mined? Are there environmental factors that influence susceptibility to alcohol? In an attempt to answer-these(More)
As Gibson and Oakeshott l • 2 indicated earlier in this volume, a wide range of biochemical and behavioural responses follow alcohol ingestion and some of these are correlated with such factors as age, sex, body build and drinking experience. However, there is little quantitative information on the relationships amongst the various responses, the extent of(More)
Geographic variation in Esterase-6 (Est-6) and Phosphoglucomutase (Pgm) gene frequencies in Australasian populations of Drosophila melanogaster are compared with analogous data collated from 16 previous reports for North America and Europe/Asia. A large-scale latitudinal cline is found on all three zoogeographic zones for Est-6 and overall, Est-61.00(More)
Proton MR spectra of the basal ganglia were obtained from 28 patients, 24 male and 14 female, median age 16.3 months (5 weeks to 31 years). They included 17 patients with normal MRI of the basal ganglia without metabolic disturbance (control group) and 11 patients with various metabolic diseases: one case each of high serum sodium and high serum osmolarity,(More)
Monozygotic twins with fumarate hydratase deficiency presenting with profound hypotonia and developmental delay are reported. This rare organic aciduria has been previously described in random case reports, although, to our knowledge, these are the first reported monozygotic twins and gene testing revealed a novel mutation in both. During their course, one(More)
Verbal and performance scores in a standard intelligence test (WAIS) were considered in relation to patterns of hand preference (measured by questionnaire) in a large sample of the general population. Left-handers and mixed-handers did not obtain lower scores than right-handers. Indeed, there was a tendency for subjects who reported that they could use(More)