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This program is free software; you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version. This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied(More)
This program is free software; you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version. This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied(More)
BACKGROUND Randomly shuffled sequences are routinely used in sequence analysis to evaluate the statistical significance of a biological sequence. In many cases, biologists need sophisticated shuffling tools that preserve not only the counts of distinct letters but also higher-order statistics such as doublet counts, triplet counts, and, in general, k-let(More)
BACKGROUND Very frequently the same biological system is described by several, sometimes competing mathematical models. This usually creates confusion around their validity, ie, which one is correct. However, this is unnecessary since validity of a model cannot be established; model validation is actually a misnomer. In principle the only statement that one(More)
This paper discusses the results of an empirical evaluation assessing 3D male and female embodied conversational agents that were formally dressed and casually dressed in three interactive VRML retail environments – a cinema box-office, a travel agency and a bank. Participants completed tasks in each application by conversing with the agents after which(More)
Synthetic Biology is the 'Engineering of Biology' - it aims to use a forward-engineering design cycle based on specifications, modelling, analysis, experimental implementation, testing and validation to modify natural or design new, synthetic biology systems so that they behave in a predictable fashion. Motivated by the need for truly plug-and-play(More)
B r a n don B lodg et, J a m es A n der s on Pa tr ick L y s a g h t T ob ia s B eck er U n iv ers ität K arls ru h e (T H), K ais ers traß e 1 2-7 6 1 3 1 K arls ru h e, G erm an y ABSTRACT Modular systems implemented on Field-Programmable G ate A rrays c an benefi t from being able to load and unload modules at run-time, a c onc ept th at is of muc h(More)
Biological system models are routinely developed in modern systems biology research following appropriate modelling/experiment design cycles. Frequently these take the form of high-dimensional nonlin-ear Ordinary Differential Equations that integrate information from several sources; they usually contain multiple timescales making them difficult even to(More)
We introduce a method for analyzing large-scale power systems by decomposing them into coupled lower order subsystems. This reduces the computational complexity of the analysis and enables us to scale the Sum of Squares programming framework for nonlinear system analysis. The method constructs subsystem Lyapunov functions which are used to estimate the(More)