James Alexander Ross

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Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling.

David C. Hay, Judy Fletcher, +14 authors John Peter Iredale
Proceedings of the National Academy of Sciences…
2008

Human embryonic stem cells (hESCs) are a valuable source of pluripotential primary cells. To date, however, their homogeneous cellular differentiation to specific cell types in vitro has proven… (More)

Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.

David C. Hay, Debiao Zhao, +8 authors Wei Cui
Stem cells
2008

The potential to differentiate human embryonic stem cells (hESCs) in vitro to provide an unlimited source of human hepatocytes for use in biomedical research, drug discovery, and the treatment of… (More)

Acute-phase protein response and survival duration of patients with pancreatic cancer.

J Stuart Falconer, K. C. Fearon, +4 authors D. Camille Carter
Cancer
1995

BACKGROUND Current methods to predict survival duration of patients with pancreatic cancer are limited. The aim of this study was to determine whether certain nutritional indices and the acute-phase… (More)

The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer

Matthew D Barber, James Alexander Ross, Anne Coble Voss, Michael John Tisdale, K. C. Fearon
British Journal of Cancer
1999

SummaryPrevious studies have suggested that administration of oral eicosapentaenoic acid (EPA) will stabilize weight in patients with advanced pancreatic cancer. The aim of the present study was to… (More)

Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer.

J Stuart Falconer, K. C. Fearon, C. E. Plester, James Alexander Ross, D. Camille Carter
Annals of surgery
1994

OBJECTIVE To determine whether resting energy expenditure (REE) is increased in cachectic patients with pancreatic cancer and to define the relation of tumor necrosis factor (TNF) and interleukin-6… (More)

A novel oral tracer procedure for measurement of habitual myofibrillar protein synthesis.

Alisdair J. MacDonald, Alexandra C. Small, +5 authors T. D. Preston
Rapid communications in mass spectrometry : RCM
2013

RATIONALE Conventionally, myofibrillar protein synthesis is measured over time periods of hours. In clinical studies, interventions occur over weeks. Functional measures over such periods may be more… (More)

Generation of functional human hepatic endoderm from human induced pluripotent stem cells.

Gareth J. Sullivan, David C. Hay, +14 authors Ian Wilmut
Hepatology
2010

UNLABELLED With the advent of induced pluripotent stem cell (iPSC) technology, it is now feasible to generate iPSCs with a defined genotype or disease state. When coupled with direct differentiation… (More)

Forms and functions of CD44.

Gillian Borland, James Alexander Ross, Karen Guy
Immunology
1998

Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells.

Ewen M Harrison, Stephen J McNally, Luke R. Devey, Oliver J Garden, James Alexander Ross, Stephen J. Wigmore
The FEBS journal
2006

Heme oxygenase-1 catalyzes the breakdown of heme and is protective in models of kidney transplantation. In this study we describe the induction of heme oxygenase-1 mRNA and protein by insulin.… (More)

Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines.

J Stuart Falconer, James Alexander Ross, K. C. Fearon, Richard Anthony Hawkins, M G O'riordain, D. Camille Carter
British Journal of Cancer
1994

A number of polyunsaturated fatty acids have been shown to inhibit the growth of malignant cells in vitro. To investigate whether fatty acids modify the growth of human pancreatic cancer, lauric,… (More)

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