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Fifteen human X-chromosome-specific DNA fragments, localized to particular regions of that chromosome, were used to search for restriction fragment length polymorphisms. A screening panel prepared by… (More)
Highly accurate gene mapping techniques need to be developed to clone disease genes with unknown defective products. The classical pedigree method and methods based on cytologically observable… (More)
Recombinant libraries constructed from the DNA of individual metaphase chromosomes that had been partially purified by fluorescence activated flow sorting have been used to study gene amplification… (More)
Lega l philosophy i s viewed as i r r e l e v a n t by v i r t u a l l y everyone except f o r l e g a l philosophers. In t h i s t h e s i s , I suggest that the main reason f o r t h i s i s l e g… (More)
Recombinant DNA techniques provide new approaches to the diagnosis and analysis of inherited human diseases associated with mental retardation. Examples of such diseases include the Lesch-Nyhan… (More)