James A. Swenberg

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.

Shinsuke Ito, Li Shen, +5 authors Yi Zhang
Science
2011

5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic imprinting, and suppression of transposable elements. 5mC can be converted to 5-hydroxymethylcytosine (5hmC) by the… (More)

Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure.

William David Kerns, Kenneth L. Pavkov, D J Donofrio, Edward J. Gralla, James A. Swenberg
Cancer research
1983

Groups of approximately 120 male and 120 female Fischer 344 rats and C57BL/6 X C3H F1 mice were exposed by inhalation to 0, 2.0, 5.6, and 14.3 ppm of formaldehyde gas 6 hr/day, 5 days/week, for 24… (More)

Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells.

Thomas M. Monticello, James A. Swenberg, +6 authors Kevin T. Morgan
Cancer research
1996

Formaldehyde induces nonlinear, concentration-related increases in nasal epithelial cell proliferation and squamous cell carcinomas (SCC) in rats. A formaldehyde carcinogenicity study was conducted… (More)

Triclosan: a critical review of the experimental data and development of margins of safety for consumer products.

Joseph V. Rodricks, James A. Swenberg, Joseph Francis Borzelleca, Robert R. Maronpot, Annette M. Shipp
Critical reviews in toxicology
2010

Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether) is an antibacterial compound that has been used in consumer products for about 40 years. The tolerability and safety of triclosan has been… (More)

Standardizing global gene expression analysis between laboratories and across platforms

Theodore Bammler, Richard P. Beyer, +61 authors Helmut Zarbl
Nature Methods
2005

To facilitate collaborative research efforts between multi-investigator teams using DNA microarrays, we identified sources of error and data variability between laboratories and across microarray… (More)

Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry.

Hasan Koç, M. J. Mar, Asoka Ranasinghe, James A. Swenberg, Steven H Zeisel
Analytical chemistry
2002

Choline is important for normal membrane function, acetylcholine synthesis, lipid transport, and methyl metabolism. The U.S. National Academy of Sciences recently set requirements for choline in the… (More)

Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.

John R. Ridpath, Ayumi Nakamura, +13 authors Jun Nakamura
Cancer research
2007

Formaldehyde is an aliphatic monoaldehyde and is a highly reactive environmental human carcinogen. Whereas humans are continuously exposed to exogenous formaldehyde, this reactive aldehyde is a… (More)

Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia.

Kun Lu, Leonard B. Collins, Hongyu Ru, Edilberto Bermudez, James A. Swenberg
Toxicological sciences : an official journal of…
2010

Inhaled formaldehyde is classified as a known human and animal carcinogen, causing nasopharyngeal cancer. Additionally, limited epidemiological evidence for leukemia in humans is available; however,… (More)

Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions.

Julie K. Horton, Donna F Joyce-Gray, Brian F Pachkowski, James A. Swenberg, Samuel H. Wilson
DNA repair
2003

Monofunctional alkylating agents react with DNA by S(N)1 or S(N)2 mechanisms resulting in formation of a wide spectrum of cytotoxic base adducts. DNA polymerase beta (beta-pol) is required for… (More)

DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration.

Lilian C. Calderon-Garciduenas, Robert R. Maronpot, +9 authors James A. Swenberg
Toxicologic pathology
2003

Acute, subchronic, or chronic exposures to particulate matter (PM) and pollutant gases affect people in urban areas and those exposed to fires, disasters, and wars. Respiratory tract inflammation,… (More)

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