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Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341
Although the biochemical targets of most drugs are known, the biological consequences of their actions are typically less well understood. In this study, we have used two whole-genome technologies inExpand
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Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis
Transthyretin (TTR) transports the retinol-binding protein–vitamin A complex and is a minor transporter of thyroxine in blood. Its tetrameric structure undergoes rate-limiting dissociation andExpand
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The Saga of Relocatable Classrooms.
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Combination of the fastening tab and stent deployment mechanism
A stent comprising at least a segment of the substantially cylindrical stent (310, 320, 330) having modified vertices (1300), modified vertices including first sections (1302), the second sectionsExpand
Inhibition de la toxicité de l'alpha-synucléine
La presente invention concerne des composes et des compositions destines au traitement ou a l'amelioration d'un ou de plusieurs symptomes associes a la toxicite de l'α-synucleine, de maladiesExpand