James A. Coker | Semantic Scholar

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Transcriptional profiling of the model Archaeon Halobacterium sp. NRC-1: responses to changes in salinity and temperature

James A. Coker, Priya Dassarma, Jeffrey Kumar, Jochen A. Müller, Shiladitya DasSarma
Saline systems
2007

BackgroundThe model halophile Halobacterium sp. NRC-1 was among the first Archaea to be completely sequenced and many post-genomic tools, including whole genome DNA microarrays are now being applied… (More)

Biochemical characterization of a beta-galactosidase with a low temperature optimum obtained from an Antarctic arthrobacter isolate.

James A. Coker, Peter P. Sheridan, Jennifer Loveland-Curtze, Kevin R. Gutshall, Ann J. Auman, Jean E. Brenchley
Journal of bacteriology
2003

A psychrophilic gram-positive isolate was obtained from Antarctic Dry Valley soil. It utilized lactose, had a rod-coccus cycle, and contained lysine as the diamino acid in its cell wall. Consistent… (More)

Genetic and transcriptomic analysis of transcription factor genes in the model halophilic Archaeon: coordinate action of TbpD and TfbA

BackgroundArchaea are prokaryotic organisms with simplified versions of eukaryotic transcription systems. Genes coding for the general transcription factors TBP and TFB are present in multiple copies… (More)

Terrestrial models for extraterrestrial life: methanogens and halophiles at Martian temperatures

Iain Reid, William B. Sparks, +17 authors Shiladitya Dassarma
2006

Cold environments are common throughout the Galaxy. We are conducting a series of experiments designed to probe the low-temperature limits for growth in selected methanogenic and halophilic Archaea.… (More)

The information transfer system of halophilic archaea.

Melinda D. Capes, James A. Coker, +6 authors Shiladitya Dassarma
Plasmid
2011

Information transfer is fundamental to all life forms. In the third domain of life, the archaea, many of the genes functioning in these processes are similar to their eukaryotic counterparts,… (More)

Protein engineering of a cold-active β-galactosidase from Arthrobacter sp. SB to increase lactose hydrolysis reveals new sites affecting low temperature activity

James A. Coker, Jean E. Brenchley
Extremophiles
2006

We examined variants of an especially cold-active β-galactosidase (BgaS) to better understand features affecting enzyme activity at temperature extremes. We targeted locations corresponding to a… (More)

Multiple replication origins of Halobacterium sp. strain NRC-1: properties of the conserved orc7-dependent oriC1.

James A. Coker, Priya Dassarma, +8 authors Shiladitya Dassarma
Journal of bacteriology
2009

The eukaryote-like DNA replication system of the model haloarchaeon Halobacterium NRC-1 is encoded within a circular chromosome and two large megaplasmids or minichromosomes, pNRC100 and pNRC200. We… (More)

Microbial Growth with Multiple Stressors

Microorganisms inhabit nearly all environments on Earth, adapting sometimes to a single stressful condition and at other times to coincident stresses. When faced with a single stress, thermophilic… (More)

Dissection of the regulatory mechanism of a heat-shock responsive promoter in Haloarchaea: a new paradigm for general transcription factor directed archaeal gene regulation

Qiuhe Lu, Jing Han, +4 authors Hua Xiang
Nucleic acids research
2008

Multiple general transcription factors (GTFs), TBP and TFB, are present in many haloarchaea, and are deemed to accomplish global gene regulation. However, details and the role of GTF-directed… (More)

Genome sequences of Halobacterium species.

Wailap V. Ng, Brian R Berquist, +4 authors Shiladitya Dassarma
Genomics
2008