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BACKGROUND AND METHODS Pain is often inadequately treated in patients with cancer. A total of 1308 outpatients with metastatic cancer from 54 treatment locations affiliated with the Eastern Cooperative Oncology Group rated the severity of their pain during the preceding week, as well as the degree of pain-related functional impairment and the degree of(More)
Technology studies and the user-oriented 'wing' of computer science have largely shared a 'heroic', albeit critical, vision of computer system design: that designers inscribe particular views of the user, user activities and priorities into the artefact, but these are often 'the wrong values', based on an inadequate or misleading view of the user and their(More)
Anatomically-based models for physical and geometric reconstruction of humans and other animals The relationship between the design elements of form and function is fundamental in producing new insights and understanding of the objects we encounter every day. Of particular interest is the study of human and animal anatomy, and how the elegance of shape and(More)
The process of cardiac remodeling in response to cardiac injury and/or persistent elevations in wall stress generally relates to the progressive changes that occur in ventricular chamber dimensions and the various components of the myocardium, in particular the cardiomyocytes and the extracellular matrix. Volume overload, pressure overload or myocardial(More)
Cardiovascular complications are a leading cause of death in patients with type 2 diabetes mellitus (T2DM). Diastolic dysfunction is one of the earliest manifestations of diabetes-induced changes in left ventricular (LV) function, and results from a reduced rate of relaxation and increased stiffness. The mechanisms responsible for increased stiffness are(More)
MicroRNAs regulate diverse cellular processes and play an integral role in cancer pathogenesis. Genomic variation within miRNA target sites may therefore be important sources for genetic differences in cancer risk. To investigate this possibility, we mapped HapMap single nucleotide polymorphisms (SNP) to putative miRNA recognition sites within genes(More)
PROBLEM/CONDITION Although chronic fatigue syndrome (CFS) has been recognized as a cause of morbidity in the United States, the etiology of CFS is unknown. In addition, information is incomplete concerning the clinical spectrum and prevalence of CFS in the United States. REPORTING PERIOD COVERED This report summarizes CFS surveillance data collected in(More)
The aim of this study was to evaluate the clinical efficacy and safety of docetaxel (Taxotere) in patients with adenocarcinoma of the upper gastrointestinal tract previously untreated with cytotoxic chemotherapy. Docetaxel 100 mg m-2 was administered as a 1 hour intravenous (IV) infusion every 3 weeks to 41 patients. Patients were premedicated prior to each(More)
Sharing research resources of different kinds, in new ways, and on an increasing scale, is a central element of the unfolding e-Research vision. Web 2.0 is seen as providing the technical platform to enable these new forms of scholarly communications. We report findings from a study of the use of Web 2.0 services by UK researchers and their use in novel(More)