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Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in cancer cells and molecular markers of drug response. Data(More)
A general framework is proposed for using precipitation estimates from NEXRAD weather radars in raingage network design. NEXRAD precipitation products are used to simulate space-time rainfall elds, which can besampled by hypothetical raingage networks. A stochastic model is used to simulate gage observations from areal-average precipitation for radar grid(More)
—Independent component analysis (ICA) has shown success in blind source separation and channel equalization. Its applications to remotely sensed images have been investigated in recent years. Linear spectral mixture analysis (LSMA) has been widely used for subpixel detection and mixed pixel classification. It models an image pixel as a linear mixture of(More)
The impact of future anthropogenic forcing on the frequency of tropical storms in the North Atlantic basin has been the subject of intensive investigation. However, whether the number of North Atlantic tropical storms will increase or decrease in a warmer climate is still heavily debated and a consensus has yet to be reached. To shed light on this issue,(More)
[1] The number of North Atlantic tropical storms lasting 2 days or less exhibits a large increase starting from the middle of the 20th century, driving the increase in recorded number of tropical storms over the past century. Here we present a set of quantitative analyses to assess whether this behavior is more likely associated with climate variability/(More)
BACKGROUND The Ensembl web site has provided access to genomic information for almost 10 years. During this time the amount of data available through Ensembl has grown dramatically. At the same time, the World Wide Web itself has become a dramatically more important component of the scientific workflow and the way that scientists share and access data and(More)