Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in cancer cells and molecular markers of drug response. Data… (More)
—Independent component analysis (ICA) has shown success in blind source separation and channel equalization. Its applications to remotely sensed images have been investigated in recent years. Linear spectral mixture analysis (LSMA) has been widely used for subpixel detection and mixed pixel classification. It models an image pixel as a linear mixture of… (More)
Tracking animals over large temporal and spatial scales has revealed invaluable and spectacular biological information, particularly when the paths and fates of individuals can be monitored on a global scale. However, only large animals (greater than approximately 300 g) currently can be followed globally because of power and size constraints on the… (More)
BACKGROUND The Ensembl web site has provided access to genomic information for almost 10 years. During this time the amount of data available through Ensembl has grown dramatically. At the same time, the World Wide Web itself has become a dramatically more important component of the scientific workflow and the way that scientists share and access data and… (More)
This paper identifies the basic notions involved in the automatic generation of logic diagrams. A system (ALDGS) for generating logic diagrams automatically is described and sample diagrams are given.
BACKGROUND It is commonly held that men delay help seeking because they are ignorant about and disinterested in their health. However, this discussion has not been informed by men's lay perspectives, which have remained almost entirely absent from scholarship relating to men's help seeking practices. METHODS In this qualitative paper, we draw on… (More)
OBJECTIVE To assess the psychosocial impact of the diagnosis of either localised or metastatic prostate cancer (PCA) on patients and their female partners. DESIGN Observational, prospective study at Time 1 and 6 months later at Time 2 of two groups of couples facing PCA. Time 1 was when patients were first diagnosed with histologically confirmed localised… (More)