James A. O’Neill

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The metabolism and disposition of the first-in-class DOT1L inhibitor, EPZ-5676 (pinometostat), was investigated in rat and dog. Metabolite profiles were compared with those from adult patients in the first-in-man phase 1 study as well as the cross-species metabolism observed in vitro. EPZ-5676 was administered to rat and dog as a 24-h IV infusion of(More)
Ž . A method for analyzing low abundances of the platinum group elements PGEs and gold has been developed using Ž . cation exchange chromatography and ultrasonic nebulization inductively coupled plasma mass spectrometry USN-ICP-MS . Ultrasonic nebulization increases sensitivity over regular pneumatic nebulization so that resolvable signals above background(More)
Denitrovibrio acetiphilus N2460T is one of the few members of the phylum Deferribacteres with a sequenced genome. N2460T was capable of growing with dimethyl sulfoxide, selenate, or arsenate provided as a terminal electron acceptor, and we identified 15 genes that could possibly encode respiratory reductases for these compounds. The protein encoded by one(More)
BACKGROUND Atrial fibrillation can be categorized into nonpermanent and permanent atrial fibrillation. There is less information on permanent than on nonpermanent atrial fibrillation patients. This analysis aimed to describe the characteristics and current management, including the proportion of patients with successful atrial fibrillation control, of these(More)
Ischaemic stroke is one of the commonest causes of morbidity and mortality worldwide and around a fifth of events can be attributed to a cardioembolic source. This is typically due to atrial fibrillation (AF), the most common sustained cardiac arrhythmia. However, AF can, at times, be difficult to detect due to a relative lack of symptoms and the fact that(More)
Low back pain has been quite prevalent in the general population. Chronic low back pain can be defined as back pain lasting for more than 12 weeks. For chronic symptoms, fusion surgeries are the most common surgeries to alleviate the pain. Visual Analog Scale (VAS) is a measurement for subjective characteristics or attitudes that can be difficult to be(More)
OBJECTIVE To ascertain whether a name can influence a person's health, by assessing whether people with the surname "Brady" have an increased prevalence of bradycardia. DESIGN Retrospective, population based cohort study. SETTING One university teaching hospital in Dublin, Ireland. PARTICIPANTS People with the surname "Brady" in Dublin, determined(More)
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