James A. Howarth

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The anti-apoptotic effects of heat-shock protein (Hsp70) were assessed in SCG neurones following nerve growth factor (NGF) withdrawal. The results showed that the virally mediated expression of Hsp70 mirrored the effects of the c-Jun-N-terminal kinase (JNK) binding domain (JBD) of JNK interacting protein (an inhibitor of JNK and c-Jun activation) and(More)
Sir, At the turn of the nineteenth century, Ehrlich focused on the selective staining of malaria-infected cells over non-infected cells, with methylene blue and acridine orange. 1 On reviewing this information, two simple questions arose: why do these compounds selectively target parasite infected cells and can this information be used against the parasite?(More)
The recent development of a specific 2-[125I]-iodo-melatonin ligand has led to the identification of 125I-melatonin binding sites in the brains of numerous mammalian species. The present study reports the localization of 125I-melatonin binding sites in the brain of the dairy goat. Six previously untreated female goats, aged 5-7 years, were culled under(More)
High speed frequency dividers are critical parts of frequency synthesisers in wireless systems. These dividers allow the output frequency from a voltage controlled oscillator to be compared with a much lower external reference frequency that is commonly used in these synthesisers. Common trade-offs in high frequency dividers are speed of division, power(More)
©Samuel James Howarth 2006 ii I hereby declare that I am the sole author of this thesis. This is a true copy of the thesis, including any required final revisions, as accepted by my examiners. I understand that my thesis may be made electronically available to the public. iii ABSTRACT Overloading of the back can cause instability such that buttressing the(More)
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