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The point during development when a neuron in the central nervous system ceases to divide is a crucial early step in differentiation which may be a prerequisite for phenotypic expression. In this double-label study, which combines [3H]thymidine autoradiography with histochemical detection of endogenous dopamine, we examined the histogenesis of(More)
Octopamine synthesized in vitro from tyramine by Limulus lateral and ventral eyes was located by light microscopic and electron microscopic autoradiography in efferent fibers which innervate ventral photoreceptors and lateral eye ommatidia. Newly synthesized octopamine was released from efferent fibers in response to depolarization in high concentrations of(More)
A scientific ontology is a formal representation of knowledge within a domain, typically including central concepts, their properties, and relations. With the rise of computers and high-throughput data collection, ontologies have become essential to data mining and sharing across communities in the biomedical sciences. Powerful approaches exist for testing(More)
The biogenic amine octopamine is synthesized from both tyrosine and tyramine in the lateral, median, and ventral eyes of Limulus. The autoradiographic studies presented here were designed to locate the sites of octopamine synthesis in the ventral and lateral eyes. We found that efferent fibers, which project to ventral and lateral eyes from the central(More)
What factors affect a scientist's choice of research problem? Qualitative research in the history, philosophy, and sociology of science suggests that this choice is shaped by an " essential tension " between the professional demand for productivity and a conflicting drive toward risky innovation. We examine this tension empirically in the context of(More)
This paper describes a GEMISIS doctoral research project nearing completion at the University of Salford, U.K. and offers some preliminary findings. The aim of the project was to design an interactive multimedia application for a portable computer in a museum setting, to assess the application as an aid to interpretation and to examine its impact on the(More)
The uptake of horseradish peroxidase (HRP) into synaptic vesicles of presynaptic terminals in the inner and outer plexiform layers of isolated frog retinas was studies by electron microscopy. Uptake into the terminals of bipolar cells was found to be enhanced by exposure of the preparations to elevated concentrations of potassium ions, and by exposure to(More)