James A. Covington

Ramesh P. Arasaradnam7
Karna D. Bardhan6
Chuka U. Nwokolo4
7Ramesh P. Arasaradnam
6Karna D. Bardhan
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Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose. We have tested the efficacy of a new method to identify BAD, based on the detection of differences in volatile organic compounds (VOC) in urine headspace of BAD vs. ulcerative colitis and healthy controls. A total of 110 patients were recruited; 23 with BAD, 42 with(More)
— In this paper, we present the analog circuit design and implementation of an adaptive neuromorphic olfaction chip. An analog VLSI device with on-chip chemosensor array, on-chip sensor interface circuitry and on-chip learning neuromorphic olfactory model has been fabricated in a single chip using Austria Microsystems 0.6 µm CMOS technology. Drawing(More)
Smell is a key human sense which can significantly effect our perception of an environment. Although, typically not as developed as our other senses, the presence of a pleasant or unpleasant smell can alter the way we view a scene. Such a cross-modal effect can be substantial with parts of a scene literally going unnoticed as the smell dominates our senses.(More)
It is well known that the electronic nose can be used to identify differences between human health and disease for a range of disorders. We present a pilot study to investigate if the electronic nose and a newer technology, FAIMS (Field Asymmetric Ion Mobility Spectrometry), can be used to identify and help inform the treatment pathway for patients(More)
  • Ramesh P. Arasaradnam, Eric Westenbrink, Michael J. McFarlane, Ruth Harbord, Samantha Chambers, Nicola O’Connell +6 others
  • 2014
Coeliac disease (CD), a T-cell-mediated gluten sensitive enteropathy, affects ∼ 1% of the UK population and can present with wide ranging clinical features, often being mistaken for Irritable Bowel Syndrome (IBS). Heightened clinical awareness and serological screening identifies those with potential coeliac disease; the diagnosis is confirmed with duodenal(More)
  • Siavash Esfahani, Nidhi M. Sagar, Ioannis Kyrou, Ella Mozdiak, Nicola O’Connell, Chuka Nwokolo +3 others
  • 2016
The medical profession is becoming ever more interested in the use of gas-phase biomarkers for disease identification and monitoring. This is due in part to its rapid analysis time and low test cost, which makes it attractive for many different clinical arenas. One technology that is showing promise for analyzing these gas-phase biomarkers is the electronic(More)
Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut dysbiosis in gastrointestinal disease. Gut dysbiosis occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of bile acids (BA) in the gut. BA metabolites(More)
Soft rot is a commonly occurring potato tuber disease that each year causes substantial losses to the food industry. Here, we explore the possibility of early detection of the disease via gas/vapor analysis, in a laboratory environment, using a recent technology known as FAIMS (Field Asymmetric Ion Mobility Spectrometry). In this work, tubers were(More)
  • Ramesh P. Arasaradnam, Michael J. McFarlane, Courtenay Ryan-Fisher, Erik Westenbrink, Paula Hodges, Matthew G. Thomas +8 others
  • 2014
Colorectal cancer (CRC) is a leading cause of cancer related death in Europe and the USA. There is no universally accepted effective non-invasive screening test for CRC. Guaiac based faecal occult blood (gFOB) testing has largely been superseded by Faecal Immunochemical testing (FIT), but sensitivity still remains poor. The uptake of population based FOBt(More)