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In a stop signal paradigm to investigate the control of human saccades subjects were instructed to make a saccade to a visual target appearing suddenly l5 degrees to the left or to the right of the fixation point. In 25% of the trials an auditory stop signal was presented after a variable delay that required the subject to inhibit the saccade. The stop(More)
OBJECTIVE To test memory performance and executive functions in patients with childhood craniopharyngioma and hypothalamic involvement. STUDY DESIGN Using standardized neuropsychological tests, we compared cognitive performance in a group of 15 patients with childhood craniopharyngioma and known hypothalamic involvement and a group of 24 age- and(More)
Craniopharyngiomas are rare brain tumors of the sellar/suprasellar region, often adversely affecting patients' physical and psychosocial functioning. Until a few years ago, knowledge on cognitive deficits in craniopharyngioma patients was based on little valid evidence, with considerable inconsistencies across studies. Findings from recent research, with(More)
It has been shown that the rostral cingulate zone (RCZ) in humans uses both positive and negative feedback to evaluate performance and to flexibly adjust behaviour. Less is known on how the feedback types are processed by the RCZ and other prefrontal brain areas, when feedback can only be used to evaluate performance, but cannot be used to adjust behaviour.(More)
Patients with hypothalamic involvement of a sellar/parasellar tumor often suffer from cognitive and social-emotional deficits that a lesion in the hypothalamus cannot fully explain. It is conceivable that these deficits are partly due to distal changes in hypothalamic networks, evolving secondary to a focal lesion. Focusing on childhood-onset(More)
John R. Anderson proposed a correspondence between ACT-R modules and brain regions (Brain Mapping Hypothesis). Using a paradigm requiring rule-based matching of chemical structures (pseudo formulae) with their respective names, we compared ACT-R-generated blood-oxygen-level dependent (BOLD) signal curves with BOLD curves obtained from functional Magnetic(More)
Noise-vocoded speech is commonly used to simulate the sensation after cochlear implantation as it consists of spectrally degraded speech. High individual variability exists in learning to understand both noise-vocoded speech and speech perceived through a cochlear implant (CI). This variability is partly ascribed to differing cognitive abilities like(More)
Prior research suggests that acoustical degradation impacts encoding of items into memory, especially in elderly subjects. We here aimed to investigate whether acoustically degraded items that are initially encoded into memory are more prone to forgetting as a function of age. Young and old participants were tested with a vocoded and unvocoded serial list(More)
Quality of survival of childhood-onset craniopharyngioma patients is frequently impaired by hypothalamic involvement or surgical lesions sequelae such as obesity and neuropsychological deficits. Oxytocin, a peptide hormone produced in the hypothalamus and secreted by posterior pituitary gland, plays a major role in regulation of behavior and body(More)
36 37 To examine the neural correlates of contextually differing control mechanisms in saccade 38 initiation, we studied 18 subjects who performed two saccade paradigms in a pseudo-random 39 order, while their eye movements were recorded in the MRI scanner (1.5 T). In the gap task, 40 the fixation point was extinguished 200 msec prior to target onset and in(More)