Jalal K. Siddiqui

Learn More
— Suffix stripping is a pre-processing step required in a number of natural language processing applications. Stemmer is a tool used to perform this step. This paper presents and evaluates a rule-based and an unsupervised Marathi stemmer. The rule-based stemmer uses a set of manually extracted suffix stripping rules whereas the unsupervised approach learns(More)
The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related troponin modifications on the Ca(2+) binding properties of the troponin complex and the reconstituted thin(More)
Control of calcium binding to and dissociation from cardiac troponin C (TnC) is essential to healthy cardiac muscle contraction/relaxation. There are numerous aberrant post-translational modifications and mutations within a plethora of contractile, and even non-contractile, proteins that appear to imbalance this delicate relationship. The direction and(More)
Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphorylations can exhibit an expected or unexpected functional(More)
  • 1