Jakub Novák

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A major outcome of the canonical Wnt/beta-catenin-signalling pathway is the transcriptional activation of a specific set of target genes. A typical feature of the transcriptional response induced by Wnt signalling is the involvement of Tcf/Lef factors that function in the nucleus as the principal mediators of signalling. Vertebrate Tcf/Lef proteins perform(More)
The paper deals with the problem of modeling and control of nonlinear processes using the Local Model Network (LMN). The idea is based on development of the local linear models for the whole operating range of the controlled process. The nonlinear plant is then approximated by a set of locally valid sub-models, which are smoothly connected using the(More)
A simple and compact scheme for synchronization of the pump and signal pulses for short-pulse OPCPA is demonstrated. Relative timing jitter of 17 fs RMS is achieved (1% of the pump pulse duration) and the system remains locked for hours. The scheme uses a balanced optical cross correlator to detect relative delays between the pump and signal pulses and can(More)
MRC Mammalian Genetics Unit, Harwell, Oxon OX11 0RD, UK Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, UK Programmes in Developmental Biology and Genetics, The Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada Departments of Pediatrics(More)
The paper deals with the problem of modelling and control using the Local Model Network (LMN). The idea is based on development of multiple local models for the whole operating range of the controlled process. The local models are then smoothly connected using the validity or weighting functions to provide a nonlinear global model of the plant. For saving(More)
We present a stable supercontinuum (SC) generated in a bulk YAG crystal, pumped by 3 ps chirped pulses at 1030 nm. The SC is generated in a loose focus geometry in a 13 cm long YAG crystal, allowing for stable and robust single-filament generation. The SC energy stability exceeds that of the pump laser by almost a factor of 3. Additionally, we show that the(More)
We report on the design and performance of a fiber-based, multi-channel laser amplifier seed pulse distribution system. The device is designed to condition and distribute low energy laser pulses from a mode-locked oscillator to multiple, highly synchronized, high energy amplifiers integrated into a laser beamline. Critical functions such as temporal pulse(More)