Jakub Jończyk

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SUMMARY Despite the case of a 19-year-old male with a pathological subtrochanteric left femoral fracture in the course of an extensive arteriovenous malformation of the left thigh. The arteriovenous malformation was diagnosed when the patient was 16 years old. He has undergone several embolization procedures. The fracture was caused by a fall from the(More)
β-Secretase (BACE-1) constitutes an important target for search of anti-Alzheimer's drugs. The first inhibitors of this enzyme were peptidic compounds with high molecular weight and low bioavailability. Therefore, the search for new efficient non-peptidic inhibitors has been undertaken by many scientific groups. We started our work from the development of(More)
Computer simulations constitute the basis of the design and discovery of new drugs. This approach is not only significant with regards to finding new structures, but also for selecting the molecules with the highest probability of being useful in the diagnostic process and treatment of numerous diseases. In our work, we used computational software to(More)
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