Jakob Tómas Bullerjahn

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In dynamic force spectroscopy, single (bio-)molecular bonds are actively broken to assess their range and strength. At low loading rates, the experimentally measured statistical distributions of rupture forces can be analysed using Kramers' theory of spontaneous unbinding. The essentially deterministic unbinding events induced by the extreme forces employed(More)
Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile forces, propagating from the membrane through the PIP2 binding site of the FERM domain and from the(More)
Partial atomic charges on the PIP2 head group were assigned using the RESP methodology [1–3] and obtained from the REDS (RESP charge derive server [1, 2]), using the HF/6-31G* formalism (HartreeFock theory using a medium-sized basis set). The total charge on the PIP2 head group was set to -5. The total charge of one PIP2 lipid is -4 at pH 7. The remaining(More)
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