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Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study
Early inhibition of plasminogen activation leads to acute fibrinolysis shutdown with improved clot stability and is associated with increased morbidity and mortality in septic patients.
Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells*
The data suggest that aldose reductase can compensate for the loss of GLO1, which might be of clinical importance within the context of neuronal diseases caused by an impaired glyoxalase system and elevated levels of dicarbonyl species, such as MG.
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
A defective MG detoxification as a metabolic prerequisite and glyoxalase 1 alterations as a genetic susceptibility to the development of type 2 diabetes mellitus under high nutrition intake are identified.
Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans
Sensitive mass spectrometric assay for determination of 15-deoxy-Δ12,14-prostaglandin J2 and its application in human plasma samples of patients with diabetes
- Jakob Morgenstern, T. Fleming, M. Brune
- BiologyAnalytical and Bioanalytical Chemistry
- 16 November 2017
The developed LC-MS/MS method represents a new possibility to quantify 15d-PGJ2 with high specificity in human plasma samples and may contribute to a better understanding of the potential anti-inflammatory effects of 15-Deoxy-Δ12,14-prostaglandin J2 in severe long-term pro-inflammatory disorders like diabetes, cancer, or cardiovascular disease.
Diabetic Polyneuropathy Is Associated With Pathomorphological Changes in Human Dorsal Root Ganglia: A Study Using 3T MR Neurography
In this first in vivo study, DRG morphological degeneration and signal increase in correlation with neuropathy severity is found and elucidates the potential importance of MR-based DRG assessments in studying structural and functional changes in DPN.
Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.
The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology
The special role of the glyoxalase system in the context of sepsis is pointed out, with a detailed insight into the current state of research regarding the metabolic changes that entail an increased MG-production in septicemia.
Troponin T Parallels Structural Nerve Damage in Type 2 Diabetes: A Cross-sectional Study Using Magnetic Resonance Neurography
This study is the first to show that high-sensitivity troponin T (hsTNT) is a potential indicator for structural nerve damage in type 2 diabetes, and indirectly support the hypothesis that microangiopathy contributes to structural nerveDamage in T2D.