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Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
It is proposed that the FKBP5 variant–dependent alterations in HPA-axis regulation could be related to the faster response to antidepressant drug treatment and the increased recurrence of depressive episodes observed in this subgroup of depressed individuals.
Drd4 gene polymorphisms are associated with personality variation in a passerine bird
It is suggested that an association between Drd4 gene polymorphisms and animal personality variation predates the divergence of the avian and mammalian lineages and heralds the possibility of following microevolutionary changes in frequencies of behaviourally relevantDrd4 polymorphisms within populations where natural selection acts differentially on different personality types.
Genetic variation and differentiation in captive and wild zebra finches (Taeniopygia guttata)
Genotyped 1000 zebra finches from 18 captive and two wild populations at 10 highly variable microsatellite loci and found patterns of genetic similarity closely match geographical relationships, so the most pronounced differences occur between the three continents: Australia, North America, and Europe.
Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.
The data on a large number of healthy subjects suggest a clear modulation of adiponectin concentrations by variants of APM1, which are not merely a concomitant effect in the course of type 2 diabetes or coronary artery disease.
Linkage disequilibrium for different scales and applications
This review aims to explain basic LD measures and their application properties, with microsatellites having a greater power to detect LD in population isolates than SNPs.
Genetic variability in the SNCA gene influences α‐synuclein levels in the blood and brain
Evidence is provided that a‐synuclein levels are influenced by genetic variability in the promoter and 3′ region of the SNCA gene in vivo, and the “protective” genotype 259/259 of the PD‐associated promoter repeat NACP‐Repl is associated with lower protein levels in blood.
Multiple regions of α‐synuclein are associated with Parkinson's disease
α‐Synuclein is considered to play an important role in the pathogenesis of both the rare familial and the common sporadic forms of Parkinson's disease. Previous reports primarily have tested the
Heterozygosity and survival in blue tits (Cyanistes caeruleus): contrasting effects of presumably functional and neutral loci
Correlations between individual heterozygosity and estimates of survival at different life‐history stages in an open population of blue tits and zebra finch are investigated to highlight the importance of considering the characteristics of the markers used in HFC studies and confirm the mixed effects ofheterozygosity in different contexts.
Heterozygosity–fitness correlations in zebra finches: microsatellite markers can be better than their reputation
It is argued that a small panel of microsatellites with high allelic richness may better reflect an individual’s realized IBD than previously appreciated, especially in species like the zebra finch, where much of the genome is inherited in large blocks that rarely experience cross‐over during meiosis.
Identification of a gene associated with avian migratory behaviour
The consistency of results among different populations and levels of analysis suggests that ADCYAP1 is one of the genes controlling the expression of migratory behaviour, and the multiple described functions of the gene product indicate that this gene might act at multiple levels modifying the shift between migratory and non-migratory states.