Jake Yeung

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Genomic analyses of hundreds of prostate tumors have defined a diverse landscape of mutations and genome rearrangements, but the transcriptomic effect of this complexity is less well understood, particularly at the individual tumor level. We selected a cohort of 25 high-risk prostate tumors, representing the lethal phenotype, and applied deep RNA-sequencing(More)
A key challenge in cancer genomics is the identification and prioritiza-tion of genomic aberrations that potentially act as drivers of cancer. In this paper we introduce HIT'nDRIVE, a combinatorial method to identify aberrant genes that can collectively influence possibly distant " outlier " genes based on what we call the " random-walk facility location "(More)
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