Genomic analyses of hundreds of prostate tumors have defined a diverse landscape of mutations and genome rearrangements, but the transcriptomic effect of this complexity is less well understood, particularly at the individual tumor level. We selected a cohort of 25 high-risk prostate tumors, representing the lethal phenotype, and applied deep RNA-sequencing… (More)
A key challenge in cancer genomics is the identification and prioritiza-tion of genomic aberrations that potentially act as drivers of cancer. In this paper we introduce HIT'nDRIVE, a combinatorial method to identify aberrant genes that can collectively influence possibly distant " outlier " genes based on what we call the " random-walk facility location "… (More)
Hit'ndrive: Multi-driver gene prioritization based on hitting time. The multi-agent rotor-router on the ring: a deterministic alternative to parallel random walks. Balls-into-bins with nearly optimal load distribution.