Jake Wilfred Rigby

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Radioiodinated synthetic atrial natriuretic factor (ANF) bound to a single class of high affinity binding sites in the plasma membrane from bovine adrenal cortex with a KD of 7.4 X 10(-10) M. The binding affinities of related peptides showed close parallelism to their potencies in natriuretic and vasorelaxant activities. Incubation of adrenal membranes with(More)
The effect of once-daily dosage of the two most widely prescribed cardioselective beta-adrenoceptor antagonists used to treat hypertension--namely, atenolol and metoprolol--was studied in nine carefully selected hypertensive outpatients. Each patient received atenolol 50 mg/day, atenolol 100 mg/day, metoprolol 100 mg/day, and metoprolol 200 mg/day in a(More)
Six elderly patients with established hypertension and six young healthy subjects were studied after 8 days of treatment with atenolol 50 mg day-1, metoprolol 50 mg day-1, oxprenolol 80 mg day-1 and propranolol 80 mg day-1. The area under the blood concentration-time curve was increased in the elderly group for each drug, but the difference was(More)
The effect of aging on the hemodynamic and sympathetic response to tracheal intubation was evaluated in 27 patients aged 18 to 80 years, ASA Class I and II, given atropine 0.4 mg and diazepam 10 mg as premedication and thiopental, 4.0 mg/kg, and succinylcholine 100 mg for anesthesia induction. Laryngoscopy and tracheal intubation was performed 60 seconds(More)
Expressed emotion (EE) is a global index of familial emotional climate, whose primary components are emotional over-involvement (EOI) and critical comments (CC)/hostility. There is a strong theoretical rationale for hypothesising that carers' guilt and shame may be differentially associated with their EOI and CC/hostility respectively. This systematic(More)
Following incubation with the beta-adrenergic agonist isoproterenol (ISO) and the alkylating agent N-ethylmaleimide (NEM), the number of beta-adrenergic receptors measured on human mononuclear leukocyte (MNL) membranes decreased. Pretreatment induced an approximately 40% loss of measurable receptors. The proportion of receptors lost was that which formed(More)
To determine whether altered beta-adrenoceptor internalization contributes to the reduced adrenergic responsiveness of the elderly, the ability to internalize beta-adrenoceptors in young and elderly men was studied by in vitro exposure of whole lymphocytes to a range of isoproterenol concentrations. The total numbers of receptors per cell were similar in(More)
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