Jairo Antônio Mazza

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The antistaphylococcal activity of LY146032 was tested in human pus in vitro and in a murine abscess model in vivo. The drug was not degraded by pus containing Β lactamase and had equally good or better activity than nafcillin or vancomycin against Staphylococcus aureus orStaphylococcus epidermidis in vitro and in vivo. Its activity was slightly enhanced(More)
Pus was obtained from patients with polymicrobial intraabdominal abscesses or polymicrobial empyema. Physical and chemical characteristics of 12 specimens were examined, and bacterial isolates were enumerated. Pus supernatant of six specimens rapidly inactivated penicillin, cephalothin, and cefazolin. Carbenicillin and ticarcillin were similarly degraded by(More)