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  • Jaime L. Masferrer, Ben S. Zweifel, +5 authors Karen Seibert
  • Chemistry, Materials Science, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1994 (First Publication: 12 April 1994)
  • We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory responseContinue Reading
  • Daniela Salvemini, Thomas P. Misko, Jaime L. Masferrer, Karen Seibert, Mark G. Currie, Philip Needleman
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1993 (First Publication: 1 August 1993)
  • We have evaluated the role of nitric oxide (NO) on the activity of the constitutive and induced forms of cyclooxygenase (COX; COX-1 and COX-2, respectively). Induction of NO synthase (NOS) and COXContinue Reading
  • Karen Seibert, Yinjunjie Zhang, +5 authors Peter C. Isakson
  • Medicine
  • Proceedings of the National Academy of Sciences…
  • 1994 (First Publication: 6 December 1994)
  • Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory diseases, but significant side effects such as gastrointestinal erosion and renal damage limit theirContinue Reading
  • James K. Gierse, Atli Thorarensen, +17 authors Jaime L. Masferrer
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2010 (First Publication: 1 July 2010)
  • Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it is up-regulated in many inflammatory conditions, including but notContinue Reading