Jaime L. Villa

Learn More
BACKGROUND UV radiation is a risk factor for nonmelanoma skin cancer (NMSC). The relation between DNA damage and oncogenesis suggests that diminished DNA repair capacity (DRC) is involved in tumorigenesis. OBJECTIVE The purpose of this study was to test the hypothesis that a low DRC is a susceptibility factor for the development of NMSC in Puerto Rico. (More)
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), known as nonmelanoma skin cancer (NMSC), are the most common cancers worldwide. Although many factors are involved in the pathogenesis of NMSC, UV radiation is an important risk factor. A fundamental question in skin cancer research is whether varying doses of total UV radiation influence key(More)
Wynn H. Kao1,7, Adam I. Riker2, Deepa S. Kushwaha3, Kimberly Ng3, Steven A. Enkemann4, Richard Jove5, Ralf Buettner5, Pascal O. Zinn3, Néstor P. Sánchez1, Jaime L. Villa6, Alan D. D'Andrea3, Jorge L. Sánchez1, Richard D. Kennedy3, Clark C. Chen†,3, and Jaime L. Matta†,6 1Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, PR(More)
Puerto Rican residents are exposed to some of the highest levels of environmental ultraviolet radiation in the world; paradoxically, the melanoma incidence in Puerto Rico is lower than that of the US mainland. The overall objective of this case-control pilot study was to test the hypotheses that (1) persons with melanoma have a significantly lower DNA(More)
BACKGROUND Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer in the Western world. The objective of this study was to examine together germline mutations in the TP53, PTCH, and XPD genes as risk factors for developing BCC at a young age. We hypothesized that mutations in these genes significantly increase the risk of early-onset BCC (<(More)
Several species of arthropods prey upon or utilize foam nests made by leptodactylid frogs. A spider [Lycosa pampeana) enters burrows made by Leptodactylus iatinasus in Argentina and eats most of the eggs. Two genera of dytiscid beetles have representatives that lay eggs on the foam mass Q^ Physalaemus pustulosas in Guatemala; beetle larvae hatch and swim in(More)
BACKGROUND Little is known about the risk factors and exposures to aeroallergens in subjects with atopic dermatitis (AD) in Southern Puerto Rico. The objective was to determine the prevalence of skin reactions to aeroallergens and to analyze self-reported risk factors in AD patients and a nonallergic control population. METHODS A cross-sectional study was(More)