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Progressive supranuclear palsy (PSP) is a disorder of unknown pathogenesis. Familial clusters of PSP have been reported related to mutations of protein tau. We report the linkage of a large Spanish family with typical autosomal dominant PSP to a new locus in chromosome 1. Four members of this family had typical PSP, confirmed by neuropathology in one case.(More)
OBJECTIVE To evaluate the efficacy and safety profile of one 30-mg nimodipine oral tablet taken three times per day (one tablet with breakfast, one with lunch, and one with dinner) or one 150-mg cinnarizine verum oral capsule taken once each day with dinner for 12 weeks. STUDY DESIGN Comparative in a double-blind, multinational pilot study. SETTING(More)
Bradykinesia is a frequent finding in Huntington's disease (HD), but some aspects are presently unknown; including the natural evolution of bradykinesia over time and the correlation between bradykinesia and functional capacity. We studied the motor performance of 20 genetically confirmed patients with HD (age: 40+/-10.8 years; age at onset 33.6+/-11 years;(More)
Movement disorders are well known features of some dominant hereditary ataxias (HA), specially SCA3/Machado-Joseph disease and dentatorubropallidolusyan atrophy. However, little is known about the existence and classification of movement disorders in other dominant and recessive ataxias. We prospectively studied the presence of movement disorders in(More)
We used spectral, textural and photogrammetric information from very-high resolution (VHR) stereo satellite data (Pléiades and WorldView-2) to estimate forest biomass across two test sites located in Chile and Germany. We compared Random Forest model performances of different predictor sets (spectral, textural, and photogrammetric), forest inventory designs(More)
BACKGROUND Chagas disease is caused by the protozoan Trypanosoma cruzi, which is transmitted to mammal hosts by triatomine insect vectors. The goal of this study was to model the spatial distribution of triatomine species in an endemic area. METHODS Vector's locations were obtained with a rural householders' survey. This information was combined with(More)
Disentangling the contribution of corridors to landscape connectivity is crucial for adopting efficient measures in conservation, but their actual role in heterogeneous landscapes is not yet fully understood. We assessed the hypothesis that corridors, consisting of hedgerows and riparian vegetation strips, are important landscape elements promoting(More)