Proteins containing C2 domains are the sensors for Ca(2+) and PI(4,5)P2 in a myriad of secretory pathways. Here, the use of a free-mounting system has enabled us to capture an intermediate state of Ca(2+) binding to the C2A domain of rabphilin 3A that suggests a different mechanism of ion interaction. We have also determined the structure of this domain in… (More)
1 Rural livelihoods, forest law and the illegal timber trade in Honduras and Nicaragua. A case study for CIFOR/PROFOR: " Forest Law Enforcement and Rural Livelihoods " .