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- Jaime Cárcel-Trullols, Attila D Kovacs, David A. Pearce
- Biochimica et biophysica acta
- 2015
The fatal, primarily childhood neurodegenerative disorders, neuronal ceroid lipofuscinoses (NCLs), are currently associated with mutations in 13 genes. The protein products of these genes (CLN1 to… (More)
- Haihong Zhang, Takatsugu Mizumachi, +9 authors Chun-Yang Fan
- Carcinogenesis
- 2007
Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA… (More)
- Takatsugu Mizumachi, Shinsuke Suzuki, +7 authors Masahiro Higuchi
- Oncogene
- 2008
Docetaxel is one of the most effective chemotherapeutic agents against cancer; nevertheless, some patients develop resistance. Unfortunately, their causes and mechanisms remain unknown. We created… (More)
- Behjatolah Monzavi-Karbassi, Cécile Artaud, +5 authors Thomas Kieber-Emmons
- Journal of immunology
- 2005
The selective targeting of tumor-associated carbohydrate Ags by the induction of serum Abs that trigger apoptosis of tumor cells as a means to reduce circulating tumor cells and micrometastases would… (More)
Neuronal ceroid lipofuscinoses (NCL) are lysosomal storage disorders characterized by the accumulation of lipofuscin within lysosomes. Late infantile (LINCL) and juvenile (JNCL) are their most common… (More)
- Akihiro Naito, Jaime Cárcel-Trullols, Cheng-hui Xie, Teresa T Evans, Takatsugu Mizumachi, Masahiro Higuchi
- International journal of cancer
- 2008
Although the net benefits of tamoxifen in adjuvant breast cancer therapy have been proven, the recurrence of the cancer in an aggressive and hormone independent form has been highly problematic. We… (More)
- Behjatolah Monzavi-Karbassi, R Jean Hine, +11 authors Thomas Kieber-Emmons
- International journal of oncology
- 2010
Aberrant glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. Availability and composition of sugars in the… (More)
- Jaime Cárcel-Trullols, J. Steven Stanley, +5 authors Thomas Kieber-Emmons
- International journal of oncology
- 2006
The mechanisms that guide organ-specific metastases are not fully established. The aberrant expression of carbohydrates may play a fundamental role in defining the molecular mechanisms for metastases… (More)
- Anas Saadeddin, Francisca Torres-Molina, Jaime Cárcel-Trullols, Amparo Araico, Jordi Peris
- AAPS pharmSci
- 2004
The time-dependent elimination kinetics of all-trans-retinoic acid (ATRA) has been associated with autoinduction of its metabolism and has led to the hypothesis that rapid development of acquired… (More)
- Jaime Cárcel-Trullols, Francisca Torres-Molina, Amparo Araico, Anas Saadeddin, José Esteban Peris
- Cancer Chemotherapy and Pharmacology
- 2004
Cyclosporine A (CyA) is able to inhibit P-glycoprotein (P-gp) and to increase cytotoxicity of some anticancer drugs, including etoposide. However, the effect of CyA on the distribution of etoposide… (More)