Jaime A. Palma

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Circulating microRNAs (miRNAs) have emerged as candidate biomarkers of various diseases and conditions including malignancy and pregnancy. This approach requires sensitive and accurate quantitation of miRNA concentrations in body fluids. Herein we report that enzyme-based miRNA quantitation, which is currently the mainstream approach for identifying(More)
Cell-free microRNAs (miRNAs) that circulate in the blood are promising surrogate biomarkers of disease and physiological processes. The ease of quantifying specific miRNA species using made-to-order approaches based on Taq-polymerase has led to numerous studies that have identified changes in the abundance of circulating cell-free miRNA species that(More)
MicroRNAs (miRNAs) are released from cells in association with proteins or microvesicles. We previously reported that malignant transformation changes the assortment of released miRNAs by affecting whether a particular miRNA species is released or retained by the cell. How this selectivity occurs is unclear. Here we report that selectively exported miRNAs,(More)
INTRODUCTION Brain death is generally accepted as a concept to indicate death. It was introduced about 40 years ago, and it was considered the ideal situation for donation of organs. METHODS During this time, however, there have been problems in the understanding of this concept both in the medical profession and in the general population. University(More)
Although a number of methodologies exist for Business Process Re-design (BPR), Supply Chain Re-design (SCR) and e-business process design, there is a lack of an integrated BPR methodological framework to support e-business implementation for Supply Chain Integration (SCI). This paper proposes a detailed framework that integrates a number of different(More)
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